Ceftin: Potent Antibiotic for Effective Bacterial Infection Treatment
Ceftin
| Product dosage: 250mg | |||
|---|---|---|---|
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| 60 | $3.65 | $278.00 $219.00 (21%) | 🛒 Add to cart |
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| 120 | $3.14
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Ceftin (cefuroxime axetil) is a second-generation cephalosporin antibiotic indicated for the treatment of a wide range of bacterial infections. As an ester prodrug of cefuroxime, it offers enhanced oral bioavailability, making it a versatile option in both outpatient and inpatient settings. Its broad-spectrum activity covers many Gram-positive and Gram-negative organisms, including beta-lactamase-producing strains, providing clinicians with a reliable therapeutic tool for common and more complex infections. This product card provides a comprehensive overview of Ceftin for healthcare professionals.
Features
- Active ingredient: cefuroxime axetil
- Available formulations: film-coated tablets (250 mg, 500 mg) and oral suspension (125 mg/5 mL, 250 mg/5 mL)
- Pharmacological class: second-generation cephalosporin antibiotic
- Mechanism of action: inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
- Spectrum: broad-spectrum activity against Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains
- Administration: oral route with or without food (though absorption is enhanced with food)
Benefits
- Effective against a wide range of common bacterial pathogens, reducing the need for multiple antibiotics
- High oral bioavailability and predictable pharmacokinetics support consistent dosing and therapeutic outcomes
- Demonstrated efficacy in treating respiratory tract infections, skin and soft tissue infections, and Lyme disease
- Generally well-tolerated profile with a safety record established through extensive clinical use
- Convenient twice-daily dosing supports patient adherence and treatment completion
Common use
Ceftin is commonly prescribed for the treatment of bacterial infections such as acute bacterial exacerbations of chronic bronchitis, pharyngitis/tonsillitis caused by Streptococcus pyogenes, otitis media, uncomplicated skin and skin structure infections, early Lyme disease, and uncomplicated urinary tract infections. It is also used for surgical prophylaxis in selected procedures. The choice of Ceftin should be guided by susceptibility testing where possible, especially in healthcare-associated infections.
Dosage and direction
Dosage varies based on infection severity, pathogen susceptibility, and patient factors including renal function. For most infections in adults and adolescents (≥13 years), the typical dose is 250–500 mg twice daily. For otitis media and pharyngitis/tonsillitis in pediatric patients (≥3 months), the dose is 30 mg/kg/day divided twice daily (max 1000 mg/day). Tablets should be swallowed whole; the oral suspension must be shaken well before each use. Administration with food may enhance absorption. Dosage adjustment is required in patients with renal impairment (CrCl <30 mL/min).
Precautions
Use with caution in patients with a history of gastrointestinal disease, particularly colitis. Prolonged use may result in fungal or bacterial superinfection. Ceftin should be prescribed with care in patients with known hypersensitivity to cephalosporins, penicillins, or other beta-lactam antibiotics due to potential cross-reactivity. Monitor renal function periodically during prolonged therapy. False-positive reactions for glucose in the urine may occur with Benedict’s or Fehling’s solutions but not with enzyme-based tests.
Contraindications
Ceftin is contraindicated in patients with known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation. It should not be used in patients who have experienced anaphylactic reactions to penicillins or other beta-lactam antibiotics.
Possible side effect
Common adverse reactions include diarrhea, nausea, vomiting, abdominal pain, headache, and dizziness. Less frequently, hypersensitivity reactions (rash, urticaria, pruritus), transient elevations in liver enzymes, eosinophilia, and positive Coombs test have been reported. Rare but serious side effects include Clostridioides difficile-associated diarrhea, Stevens-Johnson syndrome, and blood dyscrasias. Discontinue use if severe reactions occur.
Drug interaction
Probenecid may inhibit renal excretion of Ceftin, increasing serum concentrations. Concurrent use with potent diuretics may increase the risk of nephrotoxicity. Ceftin may reduce the efficacy of oral contraceptives; advise patients to use alternative contraception during therapy. Antacids and H2-receptor antagonists may reduce absorption; administer Ceftin at least 2 hours before these agents.
Missed dose
If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. In cases of significant overdose, hemodialysis or peritoneal dialysis may aid in removal of the drug. Treatment is supportive and symptomatic; there is no specific antidote.
Storage
Store tablets and oral suspension at controlled room temperature (20–25°C or 68–77°F). Keep the container tightly closed and protect from moisture. Reconstituted oral suspension is stable for 10 days at room temperature; do not freeze. Keep out of reach of children.
Disclaimer
This information is intended for healthcare professionals and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition or treatment options. Do not disregard professional medical advice or delay in seeking it based on information provided here.
Reviews
Ceftin has been widely studied and is regarded as an effective and generally well-tolerated antibiotic in both adult and pediatric populations. Clinical trials and post-marketing surveillance support its efficacy in approved indications, with high rates of clinical cure and microbiological eradication. Healthcare providers appreciate its broad spectrum and convenient dosing, though attention to potential gastrointestinal side effects and allergic reactions is advised. Patient adherence is generally favorable due to the twice-daily regimen.