CiproDex Ophthalmic Solution: Comprehensive Anti-Infective & Anti-Inflammatory Action
Cipro
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Synonyms | |||
CiproDex Ophthalmic Solution is a sterile, combination antimicrobial and anti-inflammatory suspension indicated for the treatment of ocular infections accompanied by significant inflammation. It combines ciprofloxacin, a broad-spectrum fluoroquinolone antibiotic, with dexamethasone, a potent corticosteroid, to address both the infectious pathogen and the associated inflammatory response. This dual-action formulation is designed for precise ophthalmic use, providing targeted therapy that reduces bacterial load while simultaneously mitigating pain, swelling, and discomfort. It is a first-line choice for clinicians managing bacterial conjunctivitis, corneal ulcers, and post-operative ocular inflammation.
Features
- Sterile ophthalmic suspension containing 0.3% ciprofloxacin (as hydrochloride) and 0.1% dexamethasone
- Preservative-free formulation in a multi-dose dropper bottle
- pH-balanced to match physiological tear film, minimizing irritation
- Broad-spectrum coverage against Gram-positive and Gram-negative ocular pathogens
- Uniform suspension ensuring consistent dosing with each administration
- Compatible with soft contact lens wear (after appropriate waiting period)
Benefits
- Rapid reduction of ocular bacterial load due to potent fluoroquinolone activity
- Effective control of inflammation, redness, and discomfort through corticosteroid action
- Decreased risk of corneal scarring and visual impairment in ulcerative conditions
- Enhanced patient compliance due to combined therapy in a single formulation
- Reduced treatment duration compared to sequential antibiotic and steroid regimens
- Prevention of potential complications from uncontrolled post-surgical inflammation
Common use
CiproDex is routinely prescribed for bacterial conjunctivitis caused by susceptible strains, particularly when significant inflammatory signs are present. It is also indicated for the treatment of corneal ulcers of bacterial origin and is widely used in ophthalmic surgery settings for prophylaxis and management of post-operative inflammation and infection risk. Its use is common in cases where both an antimicrobial and anti-inflammatory effect is deemed necessary by the treating ophthalmologist.
Dosage and direction
For bacterial conjunctivitis: Instill 1–2 drops into the conjunctival sac of the affected eye(s) every 4 to 6 hours while awake, for 7–10 days. For corneal ulcers: 1–2 drops every 1–2 hours initially while awake, with frequency tapered as healing progresses, typically over 2–3 weeks. For post-operative care: 1 drop 4 times daily beginning 24 hours after surgery and continuing through the first 2 postoperative weeks. Shake well before use. Avoid contaminating the dropper tip.
Precautions
Use under strict medical supervision; not for self-diagnosis or prolonged use without reevaluation. May mask or enhance existing infections, particularly fungal or viral. Monitor intraocular pressure with extended use due to steroid component. Use with caution in patients with corneal perforation or thinning. Avoid in patients with known hypersensitivity to any component. Not recommended in pediatric patients under 1 year of age.
Contraindications
Hypersensitivity to ciprofloxacin, other quinolones, dexamethasone, or any component of the formulation. Contraindicated in viral keratitis (including herpes simplex), fungal infections, mycobacterial infections, and untreated purulent ocular infections. Do not use following uncomplicated removal of a corneal foreign body.
Possible side effect
Common: transient burning/stinging upon instillation, conjunctival hyperemia, blurred vision, foreign body sensation, itching, taste disturbance. Less common: corneal deposits, eyelid edema, photophobia, tearing, dry eye. Rare: corneal perforation (in predisposed eyes), elevated intraocular pressure, optic nerve damage, cataract formation, superinfection.
Drug interaction
No specific systemic interactions are common with topical administration. However, concurrent use with other ocular medications should be separated by at least 5 minutes to avoid dilution or interaction. Caution with other topical steroids may potentiate IOP elevation. Not studied with topical NSAIDs.
Missed dose
Apply the missed dose as soon as remembered, unless it is nearly time for the next scheduled dose. Do not double the dose to make up for the missed one. Maintain the regular dosing schedule thereafter.
Overdose
Topical overdose is unlikely to cause systemic effects due to minimal absorption. If accidentally ingested, seek medical attention. Ocular overdose may result in increased irritation, redness, or discomfort; rinse eye gently with sterile saline if excessive application occurs.
Storage
Store at controlled room temperature 15°–30°C (59°–86°F). Protect from light. Keep bottle tightly closed. Do not freeze. Discard 30 days after opening. Keep out of reach of children.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Diagnosis and treatment should be made by a qualified healthcare provider. Use only as directed by a physician.
Reviews
(Omitted in accordance with medical compliance guidelines. Treatment efficacy and tolerability should be discussed with a prescribing ophthalmologist based on clinical evidence and individual patient factors.)