Gyne-Lotrimin

Gyne-Lotrimin is a clinically proven, over-the-counter antifungal medication specifically formulated to treat uncomplicated vulvovaginal candidiasis. Its active ingredient, clotrimazole, targets the cell membranes of Candida albicans and other susceptible fungi, disrupting their integrity and leading to fungal cell death. This topical cream provides symptomatic relief—including reduction of itching, burning, and discharge—while eradicating the underlying infection. Trusted by healthcare providers and patients for decades, Gyne-Lotrimin offers a convenient, non-prescription solution for recurrent or occasional yeast infections, with treatment typically completed within 3 to 7 days.

Features

• Contains 2% clotrimazole as the active antifungal agent
• Available in 1 oz (28 g) tube with measured-dose applicator
• Water-miscible, hypoallergenic cream base
• Designed for intravaginal and external vulvar application
• Fragrance-free, dye-free, and non-staining formulation
• Clinically demonstrated efficacy against Candida species
• Single-ingredient formulation without corticosteroids

Benefits

• Rapid relief from pruritus, erythema, and mucosal irritation within 24–48 hours
• High mycological cure rates demonstrated in clinical studies
• Convenient once-daily dosing regimen improves adherence
• Dual-action formulation treats both internal and external symptoms
• Minimal systemic absorption reduces risk of drug interactions
• Pre-measured applicator ensures proper dosage delivery

Common use

Gyne-Lotrimin is indicated for the local treatment of vulvovaginal candidiasis (vaginal yeast infections). Typical symptoms include vulvar pruritus, erythema, swelling, dysuria, dyspareunia, and abnormal vaginal discharge characterized as white, clumpy (cottage cheese-like), and odorless. The product is appropriate for immunocompetent patients experiencing uncomplicated infections without fever, pelvic pain, or pregnancy. Many patients successfully self-diagnose recurrent infections based on previous physician-confirmed episodes with identical symptomatology.

Dosage and direction

Administer one applicatorful (approximately 5 grams) intravaginally once daily, preferably at bedtime. For external vulvar symptoms, apply a thin layer of cream to affected areas twice daily. Wash hands before and after application. Insert applicator gently into vagina and depress plunger completely. Wash applicator with mild soap and warm water after each use. Continue treatment for 3 consecutive days for the 3-day formulation or 7 consecutive days for the 7-day formulation, even if symptoms improve earlier. Complete the full course of therapy to prevent recurrence.

Precautions

For external use only. Avoid contact with eyes. Discontinue use if sensitivity or irritation develops. Do not use tampons, douches, or other vaginal products during treatment as they may remove medication. Sexual intercourse should be avoided during treatment as the cream may weaken latex condoms and diaphragms. Not for use in children under 12 years. Consult physician if symptoms persist after 7 days or recur within 2 months. Patients with diabetes mellitus or immunosuppression should consult healthcare provider before use.

Contraindications

Hypersensitivity to clotrimazole or any component of the formulation. Not for use in patients with known sensitivity to imidazole antifungals. Contraindicated in patients with fever, abdominal pain, foul-smelling discharge, or symptoms suggesting complicated infection (e.g., recurrent infections, severe vulvovaginitis, non-albicans Candida species). Should not be used by pregnant women in the first trimester except under medical supervision.

Possible side effects

Mild and transient local reactions may include vaginal burning, itching, irritation, or redness. Rare cases of urinary frequency, lower abdominal cramps, headache, or skin rash have been reported. Systemic reactions are uncommon due to minimal absorption. Discontinue use and consult healthcare provider if severe irritation, swelling, or hives develop. Allergic contact dermatitis is possible in sensitive individuals.

Drug interaction

Although systemic absorption is minimal, theoretical interactions exist with CYP3A4 substrates. No clinically significant interactions have been reported with oral contraceptives, anticoagulants, or other commonly used medications. However, concurrent use with other vaginal products may alter efficacy. Avoid simultaneous use with other intravaginal antifungals or corticosteroids unless directed by physician.

Missed dose

Apply missed dose as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed application. Continue with regular dosing schedule. The antifungal activity persists between doses, so occasional missed doses are unlikely to significantly impact overall efficacy if the full course is completed.

Overdose

Topical overdose is unlikely due to limited systemic absorption. Excessive application may cause increased local irritation. If accidentally ingested, seek medical attention immediately. Gastrointestinal upset may occur with oral ingestion. No specific antidote exists; provide symptomatic and supportive care if necessary.

Storage

Store at room temperature (15–30°C or 59–86°F). Keep tube tightly closed. Do not freeze. Keep out of reach of children and pets. Discard any unused medication after completion of therapy. Do not use after expiration date printed on packaging.

Disclaimer

This product is for self-treatment of vaginal yeast infections only when the diagnosis has been previously confirmed by a physician. See healthcare provider if this is your first yeast infection, if you are under 12 years old, pregnant, diabetic, immunocompromised, or if symptoms persist after treatment. Not for systemic, oral, ophthalmic, or prolonged use. Read entire labeling before use.

Reviews

Clinical studies demonstrate 85–90% mycological cure rates at 4-week follow-up. Patients report significant symptom improvement within 48 hours of initiation. Healthcare providers frequently recommend this OTC option for uncomplicated cases due to its established efficacy profile and favorable safety record. User reviews consistently note convenience of application and rapid relief of discomfort, though some report messiness of cream formulation.