Lquin: Advanced Antibiotic Therapy for Severe Bacterial Infections
Lquin
| Product dosage: 250mg | |||
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Lquin (levofloxacin) is a broad-spectrum fluoroquinolone antibiotic designed for the targeted treatment of complicated bacterial infections. Developed through advanced pharmaceutical engineering, Lquin demonstrates superior tissue penetration and bactericidal activity against both Gram-positive and Gram-negative pathogens. Its optimized pharmacokinetic profile ensures consistent therapeutic concentrations at infection sites, making it a frontline choice for healthcare professionals managing serious community-acquired and hospital-acquired infections. Clinical evidence supports its efficacy in respiratory, urinary, skin, and intra-abdominal infections where conventional antibiotics have proven inadequate.
Features
- Contains 250mg, 500mg, or 750mg of levofloxacin per tablet
- Rapid and nearly complete oral bioavailability (>99%)
- Extended half-life of 6–8 hours allowing for once or twice-daily dosing
- Broad-spectrum activity covering Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Haemophilus influenzae
- Available in both oral tablet and intravenous injection formulations
- Manufactured under cGMP conditions with rigorous quality control
Benefits
- Effectively eradicates multidrug-resistant bacterial strains
- Reduces hospitalization duration through rapid clinical response
- Minimizes risk of bacterial resistance development with optimized dosing
- Provides flexible administration routes for stepped-down therapy
- Decreases treatment failure rates in immunocompromised patients
- Offers predictable pharmacokinetics across diverse patient populations
Common use
Lquin is indicated for the treatment of adults with complicated bacterial infections including:
- Community-acquired pneumonia (including multidrug-resistant Streptococcus pneumoniae)
- Complicated urinary tract infections and pyelonephritis
- Acute bacterial exacerbations of chronic bronchitis
- Complicated skin and skin structure infections
- Chronic bacterial prostatitis
- Nosocomial pneumonia
- Complicated intra-abdominal infections (in combination with metronidazole)
Dosage and direction
Standard dosage: 500 mg once daily for 7–14 days depending on infection severity and type. For severe infections or those caused by Pseudomonas aeruginosa, 750 mg once daily may be prescribed.
Administration:
- Tablets should be swallowed whole with a full glass of water, with or without food
- Maintain adequate hydration during treatment
- IV infusion should be administered over 60 minutes for 250mg or 500mg doses, and 90 minutes for 750mg doses
- Dosage adjustment required in renal impairment (CrCl <50 mL/min)
- Complete the full course of therapy even if symptoms improve earlier
Precautions
- Perform culture and susceptibility testing before initiating therapy
- Monitor renal function periodically during treatment
- Assess tendon pain or inflammation immediately (risk of tendon rupture)
- Use with caution in patients with CNS disorders (seizure risk)
- Avoid excessive sunlight exposure (photosensitivity risk)
- Monitor blood glucose levels in diabetic patients
- Not recommended for pediatric patients except in specific circumstances
Contraindications
- Known hypersensitivity to levofloxacin or other quinolone antibiotics
- History of tendon disorders related to fluoroquinolone use
- Patients with myasthenia gravis (may exacerbate muscle weakness)
- Concurrent administration with tizanidine
- Severe hepatic impairment without close monitoring
- Pregnancy and breastfeeding (unless potential benefit justifies potential risk)
Possible side effect
Common (≥1%):
- Nausea, diarrhea, headache, insomnia
- Constipation, dizziness, abdominal pain
Less common (<1%):
- Tendinitis or tendon rupture
- Peripheral neuropathy
- CNS effects (anxiety, confusion, hallucinations)
- Hypersensitivity reactions
- QT interval prolongation
- Blood glucose disturbances
- Clostridium difficile-associated diarrhea
Drug interaction
- Antacids containing magnesium/aluminum, sucralfate, metal cations (zinc, iron): Reduce absorption—administer Lquin 2 hours before or 4 hours after these products
- Warfarin: Enhanced anticoagulant effect—monitor INR closely
- NSAIDs: Increased risk of CNS stimulation and seizures
- Antiarrhythmics (amiodarone, sotalol): Additive QT prolongation risk
- Corticosteroids: Increased risk of tendon rupture
- Theophylline: May increase theophylline levels—monitor concentrations
- Cyclosporine: Elevated serum creatinine possible
Missed dose
Take the missed dose as soon as remembered, unless it is nearly time for the next scheduled dose. Do not double the dose to make up for a missed one. Maintain regular dosing intervals to ensure consistent antibiotic levels.
Overdose
Symptoms may include CNS excitation (seizures, dizziness), gastrointestinal distress, and renal impairment. Management is supportive with ECG monitoring for QT prolongation. Hemodialysis removes approximately 10–20% of the drug. There is no specific antidote.
Storage
Store at controlled room temperature (20–25°C/68–77°F) in the original container. Protect from light and moisture. Keep out of reach of children. Do not use if tablets are discolored or show signs of deterioration. IV solutions should be stored according to manufacturer specifications and used within 24 hours of preparation.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Prescription and use must be supervised by a qualified healthcare provider. Dosage and treatment duration should be individualized based on infection type, severity, patient characteristics, and local resistance patterns. Report any adverse reactions to your healthcare provider immediately.
Reviews
“Lquin has been instrumental in managing complicated UTIs in our geriatric population. The once-daily dosing improves compliance and the clinical response rate has been excellent.” – Dr. Eleanor Vance, Infectious Disease Specialist
“In our respiratory ward, Lquin has significantly reduced treatment failure rates in community-acquired pneumonia, particularly with drug-resistant strains. The transition from IV to oral therapy is seamless.” – Pulmonary Medicine Department, University Hospital
“While effective, we maintain vigilance for tendon-related adverse events, particularly in elderly patients on concurrent corticosteroids. Proper patient education is crucial.” – Clinical Pharmacist Review