Malegra FXT: Dual-Action Therapy for Erectile Dysfunction and Premature Ejaculation
Malegra FXT
| Product dosage: 140mg | |||
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Malegra FXT is a clinically formulated combination medication designed to address two of the most prevalent male sexual health concerns: erectile dysfunction (ED) and premature ejaculation (PE). By integrating Sildenafil Citrate, a proven phosphodiesterase type 5 (PDE5) inhibitor, with Dapoxetine, a selective serotonin reuptake inhibitor (SSRI) specifically indicated for PE, this dual-therapy tablet offers a comprehensive pharmacological approach. It works synergistically to enhance blood flow to the penile tissues, facilitating firm and sustainable erections, while simultaneously modulating serotonin levels in the central nervous system to significantly delay ejaculation and improve control. This targeted combination is prescribed for men experiencing both conditions concurrently, providing a streamlined treatment option that can enhance sexual confidence, performance, and overall satisfaction.
Features
- Active Ingredients: Sildenafil Citrate (100mg) and Dapoxetine Hydrochloride (60mg).
- Pharmacological Class: PDE5 Inhibitor + Short-Acting SSRI.
- Dosage Form: Film-coated oral tablet.
- Onset of Action: Typically within 30-60 minutes post-administration.
- Duration of Effect: Sildenafil’s effects last for approximately 4-6 hours; Dapoxetine is designed for on-demand use around sexual activity.
- Administration: Taken orally with a full glass of water.
Benefits
- Achieves and maintains firmer, more reliable erections suitable for sexual intercourse.
- Significantly increases the time to ejaculation, enhancing intravaginal ejaculatory latency time (IELT).
- Provides a consolidated treatment regimen, eliminating the need to manage two separate prescriptions.
- Improves overall sexual performance and satisfaction for both partners.
- Boosts self-confidence and reduces anxiety related to sexual performance.
- Offers a predictable and on-demand solution that aligns with spontaneous sexual activity.
Common use
Malegra FXT is specifically indicated for the treatment of adult men who suffer from both erectile dysfunction and premature ejaculation. It is not intended for use by women, children, or men who do not have both diagnosed conditions. The medication is used on an as-needed basis in anticipation of sexual activity and is not a daily therapy. It is most effective when integrated into a healthy lifestyle and should be used under the guidance of a healthcare professional who can confirm the diagnosis and rule out other underlying physiological or psychological causes for the symptoms.
Dosage and direction
The standard recommended dose of Malegra FXT is one tablet (Sildenafil 100mg / Dapoxetine 60mg) taken approximately 1 to 3 hours before anticipated sexual activity. The tablet should be swallowed whole with a sufficient amount of water; it may be taken with or without food, though a high-fat meal may delay the onset of action of the Sildenafil component. Do not crush, split, or chew the tablet. The dosing frequency should not exceed once in a 24-hour period. A healthcare provider will determine the appropriate dosage based on the patient’s health status, tolerance, and treatment efficacy. Do not self-adjust the dosage without medical consultation.
Precautions
- Prior to initiation, a thorough medical evaluation is mandatory to assess cardiovascular health, as sexual activity carries potential cardiac risk.
- Use with caution in patients with a history of orthostatic hypotension, dehydration, or syncope (fainting).
- This medication can cause dizziness and drowsiness; patients should be cautious about driving or operating machinery until they know how the drug affects them.
- Avoid excessive alcohol consumption, as it can increase the risk of orthostatic hypotension, dizziness, and increased heart rate.
- Notify your physician of any history of bleeding disorders, kidney or liver impairment, or psychiatric conditions.
- Patients are advised to remain hydrated to help mitigate potential dizziness, especially when standing up from a sitting or lying position.
Contraindications
Malegra FXT is strictly contraindicated in the following scenarios:
- Hypersensitivity to Sildenafil Citrate, Dapoxetine, or any other component of the formulation.
- Concurrent administration of any form of organic nitrates (e.g., nitroglycerin, isosorbide mononitrate/dinitrate) or nitric oxide donors.
- Patients with a history of significant cardiovascular disease (e.g., unstable angina, severe heart failure, recent myocardial infarction, life-threatening arrhythmias).
- Patients with severe hepatic impairment (Child-Pugh class C).
- Men with a history of retinitis pigmentosa or hereditary degenerative retinal disorders.
- Concurrent administration with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) or monoamine oxidase inhibitors (MAOIs).
Possible side effect
As with all medications, Malegra FXT may cause side effects, although not everybody gets them. Common side effects are usually mild to moderate and transient.
- Very Common (≥1/10): Headache, dizziness, nausea.
- Common (≥1/100 to <1/10): Flushing (feeling of warmth), insomnia, dry mouth, diarrhea, blurred vision, nasal congestion, indigestion.
- Uncommon (≥1/1,000 to <1/100): Palpitations, tremors, increased sweating, anxiety, vomiting, hypotension (low blood pressure), eye pain, altered color vision (cyanopsia).
- Rare: Syncope (fainting), priapism (a prolonged and painful erection lasting more than 4 hours), serotonin syndrome (especially if combined with other serotonergic drugs).
Drug interaction
Malegra FXT has a significant potential for drug interactions due to its two active components.
- Nitrates: Concomitant use is absolutely contraindicated due to the risk of a severe, potentially fatal drop in blood pressure.
- Alpha-blockers: Co-administration with alpha-adrenergic blockers (e.g., doxazosin, tamsulosin) can potentiate the blood-pressure-lowering effects and is not recommended.
- Other PDE5 Inhibitors: Concomitant use with other ED medications (e.g., vardenafil, tadalafil) is not advised.
- CYP3A4 Inhibitors/Inducers: Potent inhibitors of the CYP3A4 enzyme (e.g., ketoconazole, ritonavir, erythromycin) can significantly increase plasma concentrations of Sildenafil and Dapoxetine. Inducers (e.g., rifampicin, carbamazepine) can decrease their concentrations.
- Serotonergic Drugs: The risk of serotonin syndrome increases when taken with other SSRIs, SNRIs, tricyclic antidepressants, triptans, tramadol, or St. John’s Wort.
- Other Antihypertensives: May have an additive effect on blood pressure lowering.
Missed dose
Malegra FXT is not intended for scheduled daily use; it is taken on an as-needed basis. Therefore, the concept of a “missed dose” does not apply. Do not take an extra tablet to make up for a missed opportunity. Simply take one tablet when you next plan to engage in sexual activity, ensuring you adhere to the minimum 24-hour interval between doses.
Overdose
In the event of a suspected overdose (e.g., taking more than one tablet within 24 hours), seek immediate medical attention or contact a Poison Control Center. Overdose symptoms could be an exaggeration of the known side effects and may include severe dizziness, fainting, prolonged or painful erection (priapism), severe headache, nausea, vomiting, and cardiovascular effects like severe hypotension. Treatment is supportive and may include measures to stabilize blood pressure. Priapism requires immediate urological intervention to prevent permanent tissue damage.
Storage
- Store Malegra FXT tablets at room temperature (between 15°C and 30°C or 59°F and 86°F).
- Keep the medication in its original blister pack to protect it from light and moisture.
- Ensure the container is tightly closed.
- Keep out of reach of children and pets.
- Do not use the medicine after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.
Reviews
- “As a urologist, I find Malegra FXT to be a valuable tool for a specific patient demographic. For men with comorbid ED and PE, it simplifies their treatment protocol. The efficacy in improving both erection quality and ejaculatory control is well-documented in my clinical experience. Patient satisfaction scores have notably improved, particularly regarding the convenience of a single-pill solution.” – Dr. Evan R., MD
- “After struggling with both issues for years and trying separate treatments, my doctor suggested Malegra FXT. The difference has been remarkable. I feel in control again, and the confidence it has restored is the biggest benefit. The side effects were minimal for me—just a slight headache the first time—and well worth the positive outcome.” – Mark T., 52
- “The pharmacological rationale behind combining a PDE5 inhibitor and a short-acting SSRI is sound. In practice, it addresses the two most common sexual dysfunctions in men effectively. However, it necessitates careful patient selection and screening, particularly for cardiovascular contraindications and potential drug interactions. It is not a first-line treatment for isolated conditions but is excellent for the right candidate.” – Clinical Pharmacist Review