Maxalt

Maxalt is used to treat migraine which has already started.

Product dosage: 10mg
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Maxalt (rizatriptan benzoate) is a prescription medication specifically formulated for the acute treatment of migraine attacks with or without aura in adults. It belongs to the class of drugs known as selective serotonin receptor agonists (triptans), which work by narrowing blood vessels around the brain and blocking pain pathways. This targeted action helps to alleviate the debilitating pain, nausea, and sensitivity to light and sound that characterize migraines, allowing for a rapid return to normal function. It is not intended for the prevention of migraines or the treatment of other types of headache, such as cluster headaches.

Features

• Active ingredient: Rizatriptan benzoate
• Available in standard 5 mg and 10 mg orally disintegrating tablets (Maxalt-MLT) and conventional 10 mg tablets
• Rapidly disintegrating formulation for administration without water
• Selective agonist for serotonin (5-HT1B/1D) receptors
• Typically begins to relieve migraine pain within 30 minutes for many patients
• Manufactured under strict pharmaceutical quality controls

Benefits

• Provides significant relief from the intense, throbbing pain of a migraine attack.
• Effectively reduces associated migraine symptoms, including nausea, vomiting, photophobia (sensitivity to light), and phonophobia (sensitivity to sound).
• The fast-dissolving tablet format offers convenience and discretion, allowing for dose administration even when away from home or water.
• Helps restore functional ability, enabling a quicker return to work, family, and daily activities.
• Offers a targeted therapeutic approach for a condition that often does not respond adequately to ordinary pain relievers.

Common use

Maxalt is indicated for the acute treatment of migraine attacks. A migraine is more than just a bad headache; it is a complex neurological condition often characterized by moderate to severe pulsating pain, typically on one side of the head. The pain is frequently accompanied by nausea, vomiting, and extreme sensitivity to sensory stimuli. Maxalt is most effective when taken at the very first sign of a migraine headache. It is not to be used to prevent migraines or to treat hemiplegic or basilar migraines. It is crucial for patients to receive a formal diagnosis from a healthcare provider to confirm that their symptoms are indeed migraines and that Maxalt is an appropriate treatment choice.

Dosage and direction

The recommended dose for most adults is a single 10 mg tablet. For some patients, a 5 mg dose may be recommended, particularly those on certain medications or with specific health conditions. A second dose may be taken if the headache returns but not within 2 hours of the first dose. The maximum dosage in a 24-hour period should not exceed 30 mg. Tablets can be taken with or without food. The orally disintegrating tablets (Maxalt-MLT) should be placed on the tongue, where they will dissolve and be swallowed with saliva. No liquid is needed to swallow the MLT formulation. Do not break or split the MLT tablets.

Precautions

Before taking Maxalt, discuss your full medical history with your doctor. Special caution is advised for patients with risk factors for heart disease, including high blood pressure, high cholesterol, diabetes, smoking, obesity, a strong family history of heart disease, or postmenopausal status. Maxalt can cause chest, jaw, or neck tightness, which is usually non-cardiac but requires immediate medical evaluation to rule out serious heart problems. Use is not recommended in patients with uncontrolled hypertension. Be aware that Maxalt may cause dizziness or drowsiness; therefore, patients should not drive or operate heavy machinery until they know how the medication affects them. This medication should be used only when a clear diagnosis of migraine has been established.

Contraindications

Maxalt is contraindicated and must not be used in patients with:

• Ischemic heart disease (e.g., angina pectoris, history of myocardial infarction, or documented silent ischemia)
• History of stroke or transient ischemic attack (TIA)
• Peripheral vascular disease
• Ischemic bowel disease
• Uncontrolled hypertension
• Hemiplegic or basilar migraine
• Severe hepatic impairment
• Within 24 hours of administration of another medication in the triptan or ergotamine class (e.g., sumatriptan, dihydroergotamine) or a monoamine oxidase (MAO) A inhibitor, and within 2 weeks of discontinuing an MAO-A inhibitor.

Possible side effect

Like all medications, Maxalt can cause side effects, although not everybody gets them. Common side effects are usually mild to moderate and transient.

• Very common (≥1/10): Dizziness, drowsiness, fatigue.
• Common (≥1/100 to <1/10): Pain or pressure sensation in the chest, neck, throat, or jaw; nausea; dry mouth; palpitations; tachycardia (increased heart rate); flushing; feeling of warmth.
• Uncommon (≥1/1,000 to <1/100): Hypertension, hypotension, syncope (fainting), dyspnea (shortness of breath).
• Rare but serious side effects requiring immediate medical attention include symptoms of a heart attack (chest pain, shortness of breath, irregular heartbeat), symptoms of a stroke (sudden numbness/weakness, confusion, trouble speaking), severe abdominal pain, or signs of an allergic reaction (rash, hives, swelling).

Drug interaction

Maxalt has the potential to interact with several other medications, which can increase the risk of serious side effects. It is critical to inform your healthcare provider of all medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements.

• Other Triptans and Ergotamines: Concomitant use is contraindicated due to a risk of prolonged vasospastic reactions.
• Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Concomitant use may potentially increase the risk of serotonin syndrome, a rare but serious condition.
• Monoamine Oxidase (MAO) Inhibitors: Contraindicated. MAO-A inhibitors significantly increase rizatriptan plasma levels.
• Propranolol: Patients taking propranolol should use a lower 5 mg dose of Maxalt, as propranolol increases the plasma concentration of rizatriptan.

Missed dose

Maxalt is not taken on a scheduled basis; it is used only to treat an acute migraine attack as it occurs. Therefore, the concept of a “missed dose” does not apply. Do not take a dose to “make up” for a migraine you did not treat. Simply take one tablet at the onset of your next migraine attack, following the dosage instructions provided by your doctor.

Overdose

In cases of overdose, symptoms could be an extension of the drug’s adverse effects, including severe dizziness, drowsiness, fainting, slow heart rate, vomiting, and loss of coordination. There is no specific antidote for rizatriptan overdose. Treatment should consist of supportive care, including continuous ECG monitoring and management of vital signs. If an overdose is suspected, contact a poison control center or emergency room immediately.

Storage

Store Maxalt tablets at room temperature between 20°C to 25°C (68°F to 77°F), in a dry place, protected from light and moisture. Keep the tablets in their original blister pack until the moment of use to protect them from moisture and degradation. The orally disintegrating tablets are especially moisture-sensitive. Keep all medications out of the reach of children and pets. Do not flush medications down the toilet or pour them down a drain unless instructed to do so. Properly discard any expired or unused medication.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided may not cover all possible uses, directions, precautions, drug interactions, or adverse effects.

Reviews

• “As a long-time migraine sufferer, Maxalt has been a game-changer. The MLT version is so convenient when I’m at work and feel an attack coming on. It often aborts the migraine within 45 minutes if I catch it early enough.” – Sarah K., 42
• “I’ve tried other triptans, but Maxalt works the fastest for me. The chest tightness is a bit unsettling but my doctor assured me it’s a known side effect and not cardiac. The relief is worth it.” – Mark T., 38
• “It doesn’t work for every single one of my migraines, but it has a high success rate. It has given me a sense of control over my life that I didn’t have before.” – Jennifer L., 51
• “Effective, but the drowsiness afterward is significant. I have to plan to be done with my day because I will need to rest after taking it.” – David R., 45