Prednisolone: Potent Anti-Inflammatory and Immunosuppressive Therapy
Prednisolone
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $4.50 | $45.00 (0%) | 🛒 Add to cart |
| 20 | $2.50 | $90.00 $50.00 (44%) | 🛒 Add to cart |
| 30 | $1.83 | $135.00 $55.00 (59%) | 🛒 Add to cart |
| 60 | $1.00 | $270.00 $60.00 (78%) | 🛒 Add to cart |
| 90 | $0.78 | $405.00 $70.00 (83%) | 🛒 Add to cart |
| 120 | $0.71 | $540.00 $85.00 (84%) | 🛒 Add to cart |
| 180 | $0.61 | $810.00 $110.00 (86%) | 🛒 Add to cart |
| 270 | $0.56 | $1215.00 $150.00 (88%) | 🛒 Add to cart |
| 360 | $0.47
Best per pill | $1620.00 $170.00 (90%) | 🛒 Add to cart |
| Product dosage: 20mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $5.00 | $50.00 (0%) | 🛒 Add to cart |
| 20 | $2.75 | $100.00 $55.00 (45%) | 🛒 Add to cart |
| 30 | $2.00 | $150.00 $60.00 (60%) | 🛒 Add to cart |
| 60 | $1.08 | $300.00 $65.00 (78%) | 🛒 Add to cart |
| 90 | $1.00 | $450.00 $90.00 (80%) | 🛒 Add to cart |
| 120 | $0.83 | $600.00 $100.00 (83%) | 🛒 Add to cart |
| 180 | $0.72 | $900.00 $130.00 (86%) | 🛒 Add to cart |
| 270 | $0.59 | $1350.00 $160.00 (88%) | 🛒 Add to cart |
| 360 | $0.49
Best per pill | $1800.00 $175.00 (90%) | 🛒 Add to cart |
| Product dosage: 40mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 10 | $6.00 | $60.00 (0%) | 🛒 Add to cart |
| 20 | $3.25 | $120.00 $65.00 (46%) | 🛒 Add to cart |
| 30 | $2.33 | $180.00 $70.00 (61%) | 🛒 Add to cart |
| 60 | $1.33 | $360.00 $80.00 (78%) | 🛒 Add to cart |
| 90 | $1.11 | $540.00 $100.00 (81%) | 🛒 Add to cart |
| 120 | $1.00 | $720.00 $120.00 (83%) | 🛒 Add to cart |
| 180 | $0.83 | $1080.00 $150.00 (86%) | 🛒 Add to cart |
| 270 | $0.65 | $1620.00 $175.00 (89%) | 🛒 Add to cart |
| 360 | $0.58
Best per pill | $2160.00 $210.00 (90%) | 🛒 Add to cart |
Similar products
Prednisolone is a synthetic glucocorticoid medication with potent anti-inflammatory, immunosuppressive, and anti-allergic properties. It is a cornerstone therapy in managing numerous acute and chronic conditions, offering rapid symptom control and disease modification. As an intermediate-acting corticosteroid, it provides a balanced profile of efficacy and manageable duration of action, making it a versatile agent in both hospital and outpatient settings. Its ability to modulate immune responses and reduce inflammation makes it indispensable across multiple medical specialties.
Features
- Synthetic glucocorticoid with approximately 4 times the anti-inflammatory potency of hydrocortisone
- Available in multiple formulations: oral tablets, liquid solutions, ophthalmic suspensions, and topical preparations
- Intermediate-acting corticosteroid with a biological half-life of 18-36 hours
- High oral bioavailability with rapid absorption from the gastrointestinal tract
- Metabolized in the liver to inactive compounds, excreted primarily through urine
- Available in various strengths (1mg, 5mg, 10mg, 20mg, 25mg tablets) for precise dosing
Benefits
- Rapid reduction of inflammation and swelling across various tissue types
- Effective suppression of inappropriate immune responses in autoimmune disorders
- Significant improvement in respiratory function in asthma and COPD exacerbations
- Prompt control of allergic reactions and dermatological conditions
- Prevention of organ rejection in transplant patients when used in combination regimens
- Reduction of tumor-related symptoms in certain hematologic malignancies
Common use
Prednisolone is extensively used across medical specialties for conditions characterized by excessive inflammation or inappropriate immune activation. In rheumatology, it manages active rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica, and giant cell arteritis. Pulmonologists employ it for severe asthma exacerbations, COPD flare-ups, and sarcoidosis. Dermatologists use it for severe contact dermatitis, pemphigus vulgaris, and other blistering disorders. Hematologists utilize it in combination chemotherapy regimens for acute lymphoblastic leukemia and lymphomas. Additionally, it serves as primary therapy for adrenal insufficiency and inflammatory bowel disease flare-ups. Ophthalmologists prescribe ophthalmic preparations for uveitis, allergic conjunctivitis, and postoperative inflammation.
Dosage and direction
Dosage varies significantly based on condition severity, patient response, and treatment duration. For anti-inflammatory effects: 5-60 mg daily in divided doses. For immunosuppression: 1-2 mg/kg/day, often tapered based on clinical response. In acute asthma: 40-60 mg daily for 3-10 days. For rheumatoid arthritis: initial 5-10 mg daily, maintenance 5-7.5 mg daily. Always take with food to minimize gastric irritation. For once-daily dosing, administer in the morning to coincide with natural cortisol rhythm. Do not crush or chew delayed-release tablets. Taper gradually when discontinuing long-term therapy to avoid adrenal insufficiency.
Precautions
Monitor blood pressure, weight, and blood glucose regularly during therapy. Patients require periodic eye examinations for cataract and glaucoma development. Use caution in patients with diabetes mellitus, hypertension, heart failure, osteoporosis, peptic ulcer disease, or seizure disorders. Consider calcium and vitamin D supplementation to prevent bone loss. Implement gastrointestinal protection with proton pump inhibitors in high-risk patients. Vaccination with live vaccines is contraindicated during treatment. Stress-dose steroids may be required during surgery or major illness. Avoid abrupt discontinuation after prolonged use.
Contraindications
Absolute contraindications include systemic fungal infections and known hypersensitivity to prednisolone or any component of the formulation. Relative contraindications include active peptic ulcer disease, recent intestinal anastomoses, uncontrolled hypertension, congestive heart failure, Cushing’s syndrome, and primary glaucoma. Use during pregnancy requires careful risk-benefit assessment, particularly during first trimester. Avoid in patients with latent tuberculosis or untreated bacterial infections unless concomitant anti-infective therapy is administered.
Possible side effect
Common side effects include fluid retention, weight gain, hypertension, glucose intolerance, and mood changes. Gastrointestinal effects may include peptic ulceration, pancreatitis, and esophageal candidiasis. Musculoskeletal complications encompass osteoporosis, vertebral compression fractures, avascular necrosis, and myopathy. Dermatological manifestations include impaired wound healing, skin atrophy, ecchymoses, and hirsutism. Ophthalmologic effects include posterior subcapsular cataracts, glaucoma, and exophthalmos. Endocrine disturbances may involve hypothalamic-pituitary-adrenal axis suppression, Cushingoid appearance, and growth suppression in children.
Drug interaction
Significant interactions occur with CYP3A4 inducers (rifampin, phenytoin, carbamazepine) which reduce prednisolone efficacy. CYP3A4 inhibitors (ketoconazole, clarithromycin) may increase steroid levels. Concurrent use with NSAIDs increases gastrointestinal ulcer risk. Diuretics may exacerbate hypokalemia. Anticoagulant effects may be altered. Live vaccines are less effective and potentially dangerous. Insulin and oral hypoglycemic requirements may increase. Quinidine and digitalis toxicity risk increases with hypokalemia. Estrogens may enhance corticosteroid effects.
Missed dose
If a dose is missed and remembered within a few hours, take it as soon as possible. If it’s almost time for the next dose, skip the missed dose and resume regular schedule. Do not double the dose to make up for a missed one. For patients on alternate-day therapy, if a dose is missed, contact the prescribing physician for guidance. Consistent dosing is particularly important when tapering regimens.
Overdose
Acute overdose is unlikely to cause life-threatening symptoms but may exacerbate typical side effects. Management includes supportive care and symptomatic treatment. Gastric lavage may be considered if ingestion was recent. Monitor electrolyte balance, particularly potassium levels. Hemodialysis is not effective due to high protein binding. Chronic overdose manifests as Cushing’s syndrome: monitor for hypertension, hyperglycemia, fluid retention, and psychiatric symptoms. Taper gradually under medical supervision.
Storage
Store at room temperature (15-30°C or 59-86°F) in original container. Protect from light and moisture. Keep tightly closed. Do not store in bathroom or near sink. Keep all medications out of reach of children and pets. Do not freeze liquid formulations. Discard any unused medication after expiration date. Do not flush medications down toilet or pour into drain unless instructed.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting or changing any medication regimen. Dosage and treatment duration must be individualized based on specific medical condition, patient response, and risk factors. The prescriber should have complete medical history including all current medications and allergies.
Reviews
Clinical studies consistently demonstrate prednisolone’s efficacy across multiple indications. In rheumatoid arthritis trials, 70-80% of patients show significant improvement in joint swelling and pain. Asthma studies report 60-70% reduction in exacerbation rates with appropriate steroid courses. Dermatological applications show rapid improvement in 85% of patients with severe contact dermatitis. Long-term observational studies note effectiveness but emphasize the importance of monitoring for adverse effects, particularly with prolonged use above 7.5 mg daily. Patient-reported outcomes generally reflect improved quality of life despite side effect concerns.