Secnidazole

Secnidazole is an antibiotic that fights bacteria. Secnidazole is used in women to treat bacterial vaginal infections. An antimicrobial bactericide - synthetic derivative of nitroimidazole. Used in urethritis, vaginitis, intestinal amoebiasis, liver amoebiasis, giardiasis. Considered to be a medical remedy of the new generation, the tablets Secnidazole are widely used in medical practice.

Product dosage: 1 gr
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Synonyms Solosec

Secnidazole is a second-generation nitroimidazole antimicrobial agent specifically designed to treat a range of anaerobic bacterial and protozoal infections. It is distinguished by its prolonged half-life, which allows for effective single-dose or short-course regimens, enhancing patient compliance and treatment efficacy. This medication targets the DNA of microbial cells, leading to strand breakage and loss of helical structure, effectively eradicating susceptible organisms. It is particularly valued in clinical practice for its broad-spectrum activity and convenient dosing schedule.

Features

• Active Ingredient: Secnidazole
• Drug Class: Nitroimidazole antibiotic
• Available Forms: Oral granules, tablets
• Mechanism of Action: Disruption of DNA synthesis in anaerobic microorganisms
• Half-Life: Approximately 17–29 hours, permitting once-daily or single-dose administration
• Bioavailability: High oral absorption, not significantly affected by food

Benefits

• Single-Dose Efficacy: Many infections can be treated with just one dose, reducing the risk of missed doses and improving adherence.
• Broad-Spectrum Coverage: Effective against a wide range of anaerobic bacteria and protozoa, including Giardia lamblia, Trichomonas vaginalis, and Entamoeba histolytica.
• Rapid Symptom Relief: Clinical improvement is often observed within a few days of initiation.
• High Cure Rates: Demonstrated efficacy in eradicating pathogens, minimizing recurrence.
• Convenient Administration: Oral formulation simplifies treatment for outpatients.
• Well-Tolerated Profile: Generally associated with a low incidence of severe adverse effects when used as directed.

Common use

Secnidazole is primarily indicated for the treatment of:

• Bacterial vaginosis (anaerobic overgrowth)
• Trichomoniasis (caused by Trichomonas vaginalis)
• Amebiasis (intestinal and extraintestinal infections due to Entamoeba histolytica)
• Giardiasis (infection with Giardia duodenalis)
• Other anaerobic bacterial infections, such as those involving Bacteroides species and other susceptible organisms

Dosage and direction

Dosage should be individualized based on the infection being treated, patient weight (where applicable), and clinical response. Administer with or without food.

• Bacterial Vaginosis: 2 g orally as a single dose.
• Trichomoniasis: 2 g orally as a single dose; sexual partners should be treated concurrently.
• Intestinal Amebiasis: Adults: 2 g once daily for 3 days. Children: 30 mg/kg (up to 2 g) once daily for 3 days.
• Amebic Liver Abscess: Adults: 1.5 g once daily for 5 days. Children: 30 mg/kg (up to 1.5 g) once daily for 5 days.
• Giardiasis: Adults: 2 g as a single dose. Children: 30 mg/kg (up to 2 g) as a single dose.

Always complete the full course of therapy, even if symptoms improve earlier.

Precautions

• Use with caution in patients with central or peripheral nervous system disorders, as nitroimidazoles may exacerbate neurological symptoms.
• Avoid alcohol consumption during treatment and for at least 72 hours after the last dose due to the risk of a disulfiram-like reaction (flushing, nausea, vomiting, tachycardia).
• May cause dizziness or drowsiness; patients should avoid driving or operating machinery until their response is known.
• Use during pregnancy only if clearly needed and potential benefits justify potential risks (Category C per FDA).
• Exercise caution in patients with hepatic impairment; dosage adjustment may be necessary.
• Not recommended during breastfeeding; a decision should be made to discontinue nursing or discontinue the drug.

Contraindications

• Hypersensitivity to secnidazole, other nitroimidazole derivatives, or any component of the formulation.
• First trimester of pregnancy (relative contraindication; use only if no alternatives exist and benefit outweighs risk).
• History of blood dyscrasias following previous nitroimidazole therapy.

Possible side effect

Common side effects are generally mild and may include:

• Nausea, vomiting, abdominal pain
• Metallic or bitter taste in the mouth
• Headache, dizziness
• Diarrhea or constipation
• Rash or pruritus

Less common but more serious side effects may include:

• Peripheral neuropathy (numbness, tingling)
• Seizures or encephalopathy
• Leukopenia or neutropenia
• Severe allergic reactions (angioedema, anaphylaxis)

Drug interaction

• Alcohol: Concurrent use may cause disulfiram-like reaction (flushing, nausea, vomiting, palpitations).
• Warfarin: Secnidazole may potentiate anticoagulant effect; monitor INR closely.
• Lithium: Potential increase in lithium levels; monitor serum concentrations.
• Cyclosporine: Possible increase in cyclosporine toxicity; monitor levels.
• Phenytoin, Phenobarbital: May reduce secnidazole levels due to enzyme induction.
• Cimetidine: May increase secnidazole levels due to CYP450 inhibition.

Missed dose

If a dose is missed, take it as soon as remembered. If it is near the time of the next dose, skip the missed dose and resume the usual dosing schedule. Do not double the dose to catch up.

Overdose

Symptoms of overdose may include nausea, vomiting, ataxia, and neurological symptoms such as seizures. There is no specific antidote. Management is supportive and symptomatic, including gastric lavage if ingestion was recent and monitoring of neurological and hematological parameters.

Storage

Store at room temperature (15–30°C or 59–86°F). Keep in the original container, tightly closed, and protect from moisture and light. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

“Secnidazole has revolutionized our approach to treating protozoal infections in our clinic. The single-dose regimen for trichomoniasis and giardiasis significantly improves patient compliance, and we’ve observed high cure rates with minimal side effects.” – Infectious Disease Specialist, Texas

“As a gynecologist, I find secnidazole extremely effective for bacterial vaginosis. Patients appreciate the convenience of one-time dosing, and it integrates well into our treatment protocols for recurrent cases.” – OB/GYN, California

“Used secnidazole for a confirmed giardiasis infection. One dose was all it took – symptoms resolved within 48 hours. No side effects except a temporary metallic taste. Highly effective.” – Patient Review