Trandate

Trandate is used for treating high blood pressure.

Product dosage: 100mg
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Synonyms Albetol Ascool Biascor Hybloc Ibidomide Ipolab Labetaloli Labetalolo Labetalolum Labétalol Normadate Normodyne Normozide Presolol Resporito

Trandate (labetalol hydrochloride) is a comprehensive antihypertensive agent offering both alpha- and beta-adrenergic blocking properties. This dual mechanism provides clinicians with a versatile therapeutic option for managing hypertension across various patient profiles. Its balanced pharmacological profile enables effective blood pressure reduction while maintaining favorable hemodynamic stability, making it particularly valuable in clinical scenarios requiring nuanced cardiovascular control. The medication represents a well-established choice in hypertension management protocols worldwide.

Features

• Contains labetalol hydrochloride as active pharmaceutical ingredient
• Exhibits both selective alpha-1 and non-selective beta-adrenergic blocking activity
• Available in tablet formulations (100 mg, 200 mg, 300 mg)
• Demonstrates approximately 3:1 ratio of beta to alpha blockade
• Features rapid onset of action with peak effects within 2-4 hours
• Shows linear pharmacokinetics across therapeutic dosing range
• Provides 24-hour sustained blood pressure control with appropriate dosing
• Maintains negative chronotropic and inotropic effects characteristic of beta-blockers
• Exhibits peripheral vasodilatory activity through alpha-blockade
• Demonstrates minimal effect on cardiac output at rest

Benefits

• Dual mechanism action provides comprehensive blood pressure control through both reduced cardiac output and peripheral vasodilation
• Reduced peripheral resistance helps maintain organ perfusion while effectively lowering blood pressure
• Minimal reflex tachycardia due to balanced alpha and beta blockade prevents compensatory heart rate increases
• Preserved renal blood flow makes it suitable for patients with compromised renal function
• Flexible dosing regimen allows for individualized titration based on patient response and tolerance
• Established safety profile backed by decades of clinical use and post-marketing surveillance

Common use

Trandate is primarily indicated for the management of hypertension, both as monotherapy and in combination with other antihypertensive agents. It is particularly valuable in patients requiring balanced cardiovascular effects, including those with concomitant angina pectoris. The medication finds specialized application in perioperative hypertension management and is sometimes used off-label for hypertensive emergencies when intravenous administration is appropriate. Clinical practice also supports its use in pregnant patients with hypertension under careful supervision, though this requires thorough risk-benefit assessment.

Dosage and direction

Initial dosing typically begins with 100 mg twice daily, with gradual titration based on blood pressure response. Maintenance doses generally range from 200-400 mg twice daily, though some patients may require up to 2.4 g daily in divided doses. Dosage adjustments are necessary in elderly patients and those with hepatic impairment due to reduced drug clearance. Administration with food may enhance bioavailability. Patients should be advised to take Trandate at consistently spaced intervals to maintain stable plasma concentrations. Abrupt discontinuation should be avoided, with gradual dose reduction over 1-2 weeks recommended.

Precautions

Regular monitoring of blood pressure, heart rate, and cardiac function is essential during therapy. Hepatic function should be assessed periodically due to extensive hepatic metabolism. Caution is advised in patients with history of heart failure, bronchospastic diseases, diabetes mellitus, or thyrotoxicosis. Masking of hypoglycemic symptoms may occur in diabetic patients. Patients should be warned about potential dizziness or fatigue, particularly when initiating therapy or changing doses. Orthostatic hypotension may occur, especially during initial dose titration.

Contraindications

Trandate is contraindicated in patients with bronchial asthma, overt cardiac failure, cardiogenic shock, severe bradycardia, second- or third-degree heart block, and severe hepatic impairment. Additional contraindications include hypersensitivity to labetalol or any component of the formulation, and conditions associated with severe and prolonged hypotension.

Possible side effects

Common adverse reactions include fatigue (5-10%), dizziness (5-15%), nausea (5-10%), and dyspepsia (3-5%). Less frequent side effects comprise orthostatic hypotension (2-4%), bronchospasm (1-2%), bradycardia (2-3%), and sexual dysfunction (1-2%). Rare but serious adverse events include hepatotoxicity, severe hypotension, and heart block. Most side effects are dose-dependent and often diminish with continued therapy or dose adjustment.

Drug interaction

Significant interactions occur with other antihypertensive agents, potentially causing additive hypotensive effects. Concomitant use with calcium channel blockers may enhance bradycardic and hypotensive responses. Cimetidine increases labetalol bioavailability, while rifampin decreases plasma concentrations. Nitroglycerin may potentiate hypotension. Concurrent use with insulin or oral hypoglycemics may mask hypoglycemic symptoms. MAO inhibitors require careful monitoring when administered with Trandate.

Missed dose

If a dose is missed, patients should take it as soon as remembered unless it is nearly time for the next scheduled dose. Doubling of doses should be avoided. Consistent timing of administration is important for maintaining stable blood pressure control. Patients should be educated about the importance of adherence and advised to contact their healthcare provider if multiple doses are missed.

Overdose

Symptoms of overdose include severe hypotension, bradycardia, bronchospasm, and cardiac failure. Management involves cardiovascular support with appropriate monitoring. Atropine may be administered for bradycardia. Vasopressors such as norepinephrine may be required for hypotension, though epinephrine should be avoided due to potential paradoxical effects. Glucagon has been used successfully in beta-blocker overdose. Gastric lavage may be considered if ingestion was recent.

Storage

Store at controlled room temperature (20-25°C/68-77°F) in original container. Protect from light and moisture. Keep tightly closed and out of reach of children. Do not use if tablets show evidence of discoloration or physical deterioration. Proper disposal of unused medication should follow local regulations.

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Healthcare professionals should consult full prescribing information before initiating therapy. Individual patient responses may vary, and treatment decisions should be based on clinical judgment and patient-specific factors. Always follow local prescribing guidelines and regulations.

Reviews

Clinical studies demonstrate Trandate’s efficacy in reducing both systolic and diastolic blood pressure across diverse patient populations. Meta-analyses confirm its position as an effective second-line antihypertensive agent with particular utility in specific patient subgroups. Long-term follow-up data support its sustained efficacy and generally favorable tolerability profile. Real-world evidence indicates high physician satisfaction with its dual mechanism of action and flexible dosing options.