Wellbutrin: A Clinically Proven Antidepressant for Symptom Relief
Wellbutrin
| Product dosage: 300mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $2.20 | $66.00 (0%) | 🛒 Add to cart |
| 60 | $1.95 | $132.00 $117.00 (11%) | 🛒 Add to cart |
| 90 | $1.87 | $198.00 $168.00 (15%) | 🛒 Add to cart |
| 120 | $1.82 | $264.00 $219.00 (17%) | 🛒 Add to cart |
| 180 | $1.78 | $396.00 $321.00 (19%) | 🛒 Add to cart |
| 270 | $1.76 | $594.00 $474.00 (20%) | 🛒 Add to cart |
| 360 | $1.74
Best per pill | $792.00 $627.00 (21%) | 🛒 Add to cart |
Wellbutrin (bupropion hydrochloride) is a norepinephrine–dopamine reuptake inhibitor (NDRI) antidepressant medication approved by the FDA for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD). Unlike many SSRIs, it acts on different neurotransmitter systems, offering a distinct pharmacological profile that may be preferable for certain patient populations. Its unique mechanism provides effective mood elevation with a generally favorable side effect profile regarding sexual function and weight.
Features
- Active ingredient: Bupropion hydrochloride
- Available in immediate-release (IR), sustained-release (SR), and extended-release (XL) formulations
- NDRI mechanism: inhibits neuronal reuptake of norepinephrine and dopamine
- Minimal impact on serotonin reuptake
- Multiple strengths: 75 mg, 100 mg, 150 mg, 200 mg, 300 mg
- Typically administered orally, once to three times daily depending on formulation
Benefits
- Effective reduction of depressive symptoms, including low mood, anhedonia, and fatigue
- Lower incidence of sexual dysfunction compared to SSRIs
- Neutral or favorable weight profile, with some patients experiencing weight loss
- May improve concentration, motivation, and energy levels
- Approved for prevention of seasonal affective disorder with seasonal dosing
- Option for adjunctive therapy with other antidepressants to mitigate side effects
Common use
Wellbutrin is primarily indicated for the treatment of major depressive disorder in adults. It is also approved for the prevention of seasonal affective disorder. Off-label uses may include attention-deficit/hyperactivity disorder (ADHD), bipolar depression (with caution and typically alongside mood stabilizers), and as an aid for smoking cessation (under the brand name Zyban). It is not typically considered a first-line treatment for anxiety disorders and may even exacerbate anxiety in some individuals.
Dosage and direction
Dosage must be individualized based on patient response and tolerance. The usual starting dose for Wellbutrin SR is 150 mg once daily, which may be increased to 150 mg twice daily after at least three days. For Wellbutrin XL, the initial dose is 150 mg once daily, which may be increased to 300 mg once daily after several days. The maximum recommended dose is 450 mg per day, divided into doses of no more than 150 mg each for IR formulations, or 400 mg for XL (as a single daily dose). Tablets should be swallowed whole and not crushed, chewed, or divided. Administration in the morning is recommended to minimize potential insomnia.
Precautions
Patients should be monitored for worsening depression, suicidality, or unusual changes in behavior, especially at the beginning of treatment or after dosage changes. Use with caution in patients with hepatic or renal impairment, dose adjustment may be necessary. May lower seizure threshold; use extreme caution in patients with history of seizure disorder, head trauma, or concomitant medications that lower seizure threshold. May cause hypertension; periodic blood pressure monitoring is recommended. Use caution when driving or operating machinery until response is known.
Contraindications
Wellbutrin is contraindicated in patients with a known hypersensitivity to bupropion or any component of the formulation. It must not be used in patients with a current or prior diagnosis of bulimia or anorexia nervosa due to increased risk of seizure. Contraindicated in patients undergoing abrupt discontinuation of alcohol or sedatives. Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated; at least 14 days should elapse between discontinuation of an MAOI and initiation of Wellbutrin.
Possible side effects
Common side effects (≥1%) include dry mouth, nausea, insomnia, headache, dizziness, and constipation. Less frequently, tachycardia, rash, sweating, and tremor may occur. Significant but less common adverse reactions include seizures (dose-dependent), hypertension, and psychiatric reactions such as anxiety, agitation, or hallucinations. Allergic reactions, including angioedema and anaphylaxis, have been reported. Any new or worsening symptoms should be reported to a healthcare provider promptly.
Drug interaction
Wellbutrin is metabolized primarily by CYP2B6. Concomitant use with CYP2B6 inhibitors (e.g., ticlopidine, clopidogrel) may increase bupropion exposure. Inducers of CYP2B6 (e.g., ritonavir, carbamazepine) may decrease levels. May interact with drugs that lower seizure threshold (e.g., antipsychotics, antidepressants, tramadol). Use caution with levodopa and amantadine. May increase concentrations of drugs metabolized by CYP2D6 (e.g., certain antidepressants, antipsychotics, beta-blockers, and Type 1C antiarrhythmics). Avoid concomitant use with other formulations containing bupropion.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is close to the time of the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended, as it may increase the risk of adverse effects, including seizure.
Overdose
Overdose may lead to seizures, hallucinations, tachycardia, and loss of consciousness. Fatal outcomes have been reported, especially with mixed overdoses involving multiple drugs. Symptoms may be delayed in onset. Management is supportive and symptomatic; there is no specific antidote. Airway protection and ECG monitoring are essential. Activated charcoal may be considered if presented early. Contact a poison control center immediately for guidance.
Storage
Store at room temperature (20–25°C or 68–77°F), with excursions permitted between 15–30°C (59–86°F). Keep in a tightly closed container, away from light, moisture, and excessive heat. Keep out of reach of children and pets. Dispose of unused medication properly via a drug take-back program or according to FDA guidelines.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.
Reviews
Clinical trials and post-marketing surveillance demonstrate Wellbutrin’s efficacy in reducing depressive symptoms, with particular benefits noted in patients concerned about sexual side effects or weight gain associated with other antidepressants. Many patients report improved energy and focus. However, individual responses vary, and some may experience side effects such as insomnia or anxiety. It is essential that treatment be managed by a healthcare professional to ensure appropriate use and monitoring.