Accupril: Effective Blood Pressure Control for Cardiovascular Health
Accupril
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Accupril (quinapril hydrochloride) is an angiotensin-converting enzyme (ACE) inhibitor medication clinically proven to manage hypertension and heart failure. This prescription medication works by relaxing blood vessels, allowing blood to flow more smoothly and reducing the heart’s workload. Healthcare professionals frequently prescribe Accupril as part of comprehensive cardiovascular management strategies due to its demonstrated efficacy and generally favorable safety profile. Proper medical supervision is essential for optimal therapeutic outcomes.
Features
- Contains quinapril hydrochloride as active pharmaceutical ingredient
- Available in 5mg, 10mg, 20mg, and 40mg tablet strengths
- Once or twice-daily dosing regimen
- Film-coated tablets for easier swallowing
- Manufactured under strict quality control standards
- Stable at room temperature storage conditions
Benefits
- Effectively lowers elevated blood pressure to reduce cardiovascular risk
- Decreases strain on the heart muscle in heart failure patients
- May improve kidney function in hypertensive patients with diabetes
- Reduces risk of heart attack and stroke in high-risk populations
- Can be used as monotherapy or in combination with other antihypertensives
- Generally well-tolerated with established long-term safety data
Common use
Accupril is primarily indicated for the treatment of hypertension (high blood pressure) in adults. It may be used alone or in combination with thiazide diuretics. Additionally, Accupril is approved for the management of heart failure as adjunctive therapy when diuretics and digitalis provide inadequate response. Some clinicians may prescribe it for diabetic nephropathy, though this represents off-label usage requiring careful medical supervision.
Dosage and direction
The recommended initial dosage for hypertension is 10-20mg once daily. For patients on diuretic therapy or with renal impairment, initial dose should be 2.5-5mg. Dosage may be adjusted at approximately two-week intervals based on therapeutic response. Maintenance doses typically range from 20-80mg daily, administered as a single dose or divided into two doses. For heart failure, initial dose is usually 5mg twice daily, which may be increased weekly as tolerated. Tablets should be swallowed whole with water, with or without food, though consistency in administration relative to meals is recommended.
Precautions
Patients should undergo baseline renal function assessment before initiation. Regular monitoring of blood pressure, renal function, and serum potassium is essential during treatment. Caution is advised in patients with renal artery stenosis, collagen vascular diseases, or those undergoing major surgery. Angioedema may occur at any time during therapy, requiring immediate medical attention. Patients should maintain adequate hydration and avoid excessive perspiration or diarrhea that might lead to volume depletion.
Contraindications
Accupril is contraindicated in patients with known hypersensitivity to quinapril or any other ACE inhibitor. It must not be used during pregnancy, particularly in the second and third trimesters, due to risk of fetal injury and death. Additional contraindications include history of angioedema related to previous ACE inhibitor therapy and concomitant use with aliskiren in patients with diabetes.
Possible side effect
Common adverse reactions may include cough (characteristically dry and persistent), dizziness, headache, fatigue, and gastrointestinal disturbances. Less frequently, patients may experience orthostatic hypotension, hyperkalemia, rash, or taste disturbance. Serious side effects requiring immediate medical attention include angioedema, hepatotoxicity, neutropenia/agranulocytosis, and renal impairment. Symptomatic hypotension may occur particularly in volume-depleted patients.
Drug interaction
Significant interactions occur with potassium supplements, potassium-sparing diuretics, and salt substitutes containing potassium due to increased hyperkalemia risk. Nonsteroidal anti-inflammatory drugs may diminish the antihypertensive effect and increase renal impairment risk. Dual blockade of the renin-angiotensin system with ARBs or aliskiren increases adverse event risk. Lithium levels may increase during concomitant therapy. Antidiabetic medication requirements may change.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, patients should skip the missed dose and resume their regular dosing schedule. Doubling doses to make up for a missed dose is not recommended. Consistent daily administration provides optimal therapeutic effect.
Overdose
Symptoms of overdose may include severe hypotension, circulatory shock, electrolyte disturbances, and renal failure. Management involves supportive care including volume expansion with normal saline and measures to maintain blood pressure. Hemodialysis may be effective in removing quinapril and its metabolites. Patients should seek immediate medical attention if overdose is suspected.
Storage
Store at controlled room temperature (20-25°C or 68-77°F) with excursions permitted between 15-30°C (59-86°F). Keep container tightly closed and protect from moisture and light. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly dispose of any unused medication according to local regulations.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Accupril is available by prescription only and should be used under appropriate medical supervision. Individual patient responses may vary, and healthcare providers should consider the complete clinical picture when prescribing this medication. Patients should not adjust dosage or discontinue treatment without consulting their healthcare provider.
Reviews
Clinical studies demonstrate that Accupril effectively reduces blood pressure in approximately 70-80% of patients with mild to moderate hypertension. In heart failure trials, Accupril showed significant improvement in exercise tolerance and reduction in heart failure symptoms. Many clinicians report satisfactory patient tolerance and compliance with once-daily dosing. The characteristic ACE inhibitor cough remains the most frequently reported reason for discontinuation, occurring in approximately 5-15% of patients. Overall, Accupril maintains a favorable benefit-risk profile when appropriately prescribed and monitored.