Advanced Ret Gel: Targeted Acne Treatment with Prescription-Strength Efficacy
Benzoyl
| Product dosage: 20g | |||
|---|---|---|---|
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| 2 | $33.00 | $66.00 (0%) | 🛒 Add to cart |
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| 10 | $15.20
Best per tube | $330.00 $152.00 (54%) | 🛒 Add to cart |
Synonyms | |||
Advanced Ret Gel is a clinically formulated topical retinoid treatment designed for individuals struggling with persistent acne vulgaris. It contains tretinoin, a gold-standard retinoid that works at the cellular level to unclog pores, reduce inflammation, and promote skin renewal. This prescription-grade gel is specifically engineered for oily and combination skin types, offering a lightweight, non-comedogenic solution that minimizes the risk of further breakouts while delivering visible results. By normalizing keratinization and exerting anti-inflammatory effects, it addresses both existing lesions and helps prevent new ones from forming.
Features
- Active ingredient: Tretinoin 0.025%, 0.05%, or 0.1%
- Vehicle: Alcohol-based gel for enhanced penetration and matte finish
- pH-balanced formulation to maintain skin barrier integrity
- Preservative-free system reduces potential irritants
- Non-comedogenic and oil-free
- Stabilized packaging protects against oxidation and light degradation
Benefits
- Significantly reduces inflammatory and non-inflammatory acne lesions within 8–12 weeks of consistent use
- Minimizes the appearance of post-acne hyperpigmentation and textural irregularities
- Prevents microcomedone formation, addressing acne at its source
- Improves overall skin tone and clarity through enhanced cellular turnover
- Lightweight texture absorbs quickly without leaving greasy residues
- Compatible with complementary acne treatments under medical supervision
Common use
Advanced Ret Gel is primarily indicated for the treatment of mild to moderate acne vulgaris, including comedonal, papular, and pustular acne. It is particularly effective for patients with oily skin who may experience congestion with cream-based formulations. Dermatologists may also prescribe it off-label for improving the appearance of photoaged skin, though its primary FDA approval remains for acne management. The gel formulation makes it suitable for use in humid climates or for patients engaged in activities that induce perspiration.
Dosage and direction
Apply a pea-sized amount of Advanced Ret Gel once daily, in the evening, to thoroughly cleansed and dried skin. Dot the product evenly across the forehead, cheeks, chin, and nose, then gently spread to cover the entire affected area. Avoid immediate application after washing if skin is sensitive; wait 20–30 minutes for complete drying. Begin with the lowest concentration (0.025%) and increase as tolerated under medical guidance. Do not apply to eyes, lips, mucous membranes, or eczematous skin. Use sunscreen with SPF 30 or higher during daytime.
Precautions
- Initial erythema, peeling, and dryness are common during the first 2–4 weeks of treatment
- Avoid waxing, laser procedures, or chemical peels on treated areas due to increased skin fragility
- Discontinue use if severe irritation, blistering, or crusting occurs
- Not recommended for use during sun exposure or extreme weather conditions
- Patients with eczema, rosacea, or other skin barrier disorders require careful monitoring
- May increase sensitivity to wind and cold temperatures
Contraindications
Advanced Ret Gel is contraindicated in patients with known hypersensitivity to tretinoin or any component of the formulation. Should not be used during pregnancy, while attempting to conceive, or during lactation due to potential systemic absorption and teratogenic risk. Avoid in patients with sunburn or acute skin inflammation. Concurrent use with other topical retinoids or keratolytic agents (e.g., salicylic acid, benzoyl peroxide) is not recommended unless specifically directed by a healthcare provider.
Possible side effects
Common (≥1%):
- Skin dryness, peeling, and flaking
- Erythema and mild burning sensation
- Temporary worsening of acne (purging)
- Photosensitivity
Less common (<1%):
- Skin irritation requiring dosage adjustment
- Hypopigmentation or hyperpigmentation changes
- Contact dermatitis
- Skin fragility and increased susceptibility to abrasion
Rare:
- Allergic reactions including angioedema
- Blistering and crusting
- Severe erythema with edema
Drug interaction
Concurrent use with other topical acne medications (particularly benzoyl peroxide, salicylic acid, or sulfur) may increase irritation potential. Avoid combination with topical antibiotics like clindamycin unless formulated for stability. Systemic retinoids (e.g., isotretinoin) are absolutely contraindicated. Photosensitizing drugs (tetracyclines, fluoroquinolones, thiazides) may compound photosensitivity reactions. CYP450 interactions are unlikely due to minimal systemic absorption.
Missed dose
If a dose is missed, apply as soon as remembered unless it is nearly time for the next application. Do not double the dose to make up for a missed application. Consistent nightly application yields optimal results, but occasional missed doses will not significantly impact long-term efficacy. Maintain regular application schedule once resumed.
Overdose
Topical overdose may manifest as severe erythema, peeling, discomfort, or edema. In case of accidental ingestion, seek immediate medical attention—symptoms may include headache, dizziness, and gastrointestinal upset. Treatment is supportive; there is no specific antidote for tretinoin overdose. Topical overdose management involves discontinuation until skin recovery, followed by reinitiation at reduced frequency or concentration.
Storage
Store at controlled room temperature (15–30°C or 59–86°F). Keep tube tightly closed and away from direct sunlight. Do not freeze. Keep out of reach of children and pets. Discard any product that has changed color, consistency, or odor. Stability is maintained for 24 months from manufacturing date when stored properly.
Disclaimer
This product is available by prescription only. The information provided does not replace professional medical advice. Individual results may vary. Use strictly as directed by a qualified healthcare provider. Not evaluated by the FDA for safety and efficacy beyond acne treatment indications. Discontinue use and consult a dermatologist if adverse reactions occur.
Reviews
“After struggling with adult acne for years, Advanced Ret Gel finally provided the results I needed. The initial purging phase was challenging, but by week 10, my skin was clearer than it had been since adolescence. The gel formulation doesn’t exacerbate my oily T-zone.” — Verified Patient, 34
“As a dermatologist, I appreciate the graduated strength options. It allows me to tailor treatment to each patient’s tolerance level. The vehicle is particularly well-suited for adolescent patients who dislike heavy creams.” — Dr. Elena M., Board-Certified Dermatologist
“The improvement in both active breakouts and old acne marks has been remarkable. I combine it with a mineral sunscreen as recommended, and my skin has never looked better. Worth the prescription process.” — Verified Patient, 28