Allegra: Advanced Relief for Seasonal Allergy Symptoms
Allegra
| Product dosage: 120mg | |||
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| Product dosage: 180mg | |||
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Synonyms
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Allegra (fexofenadine hydrochloride) is a leading non-drowsy antihistamine specifically formulated to provide comprehensive relief from seasonal allergic rhinitis symptoms. Developed through advanced pharmaceutical research, it represents a second-generation H1-receptor antagonist with superior specificity and minimized central nervous system penetration. This medication effectively targets histamine-mediated pathways while maintaining a favorable safety profile, making it a preferred choice among healthcare providers and patients seeking reliable allergy management without sedation. Its rapid onset and prolonged duration of action ensure sustained symptom control throughout the day.
Features
- Contains fexofenadine hydrochloride as the active pharmaceutical ingredient
- Available in multiple formulations including tablets, orally disintegrating tablets, and oral suspension
- Designed for once-daily or twice-daily dosing depending on strength and indication
- Manufactured using patented manufacturing processes ensuring consistent bioavailability
- Free from sedating effects commonly associated with first-generation antihistamines
- Exhibits minimal metabolism through cytochrome P450 system
- Features rapid absorption with peak plasma concentrations achieved within 1-3 hours
- Maintains therapeutic effect for 24 hours following single-dose administration
Benefits
- Provides rapid relief from sneezing, rhinorrhea, itchy nose/palate/throat, and itchy/watery/red eyes
- Enables normal daily activities without sedation or performance impairment
- Reduces nasal congestion through effective histamine pathway blockade
- Maintains symptom control throughout day and night with single daily dosing
- Suitable for long-term management of chronic allergic conditions
- Compatible with most concomitant medications due to favorable interaction profile
Common use
Allegra is primarily indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older. These symptoms include sneezing, rhinorrhea, itchy nose/palate/throat, and itchy/watery/red eyes. Additionally, it is indicated for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. Healthcare providers may also prescribe it off-label for other histamine-mediated conditions where non-sedating antihistamine therapy is indicated. The medication is particularly valuable for patients who require alertness for occupational activities or driving.
Dosage and direction
For seasonal allergic rhinitis in adults and children 12 years and older: 60 mg twice daily or 180 mg once daily. For children 6-11 years: 30 mg twice daily. For children 2-5 years: 15 mg twice daily (oral suspension). For chronic idiopathic urticaria in adults and children 12 years and older: 60 mg twice daily. Administration should occur with water on an empty stomach, as food may decrease absorption. Tablets should be swallowed whole and not crushed or chewed. Orally disintegrating tablets should be placed on tongue immediately after opening blister pack. Dosage adjustment may be necessary in patients with renal impairment.
Precautions
Patients with renal impairment require dosage adjustment as fexofenadine is primarily eliminated renally. Use caution in elderly patients who may have decreased renal function. Although Allegra demonstrates minimal sedation, individual responses may vary, and patients should exercise caution when operating machinery until they determine their response. The medication should be used during pregnancy only if clearly needed, and caution exercised when administering to nursing women. Patients should avoid consuming fruit juices (apple, orange, grapefruit) concurrently with dosing as they may reduce bioavailability. Those with hypersensitivity to any component of the formulation should avoid use.
Contraindications
Allegra is contraindicated in patients with known hypersensitivity to fexofenadine hydrochloride or any excipients in the formulation. The medication is not recommended for children under 2 years of age for allergic rhinitis or under 6 months for urticaria. Patients with severe renal impairment (creatinine clearance less than 30 mL/min) should not use standard dosing without medical supervision. Concurrent use with aluminum and magnesium-containing antacids within 2 hours of dosing is contraindicated due to reduced absorption. The orally disintegrating formulation contains phenylalanine and is contraindicated in patients with phenylketonuria.
Possible side effects
The most commonly reported adverse reactions include headache (occurring in approximately 7% of patients), drowsiness (1.3%), and nausea (1.6%). Less frequent side effects may include dysmenorrhea, back pain, and upper respiratory tract infection. Dizziness and fatigue have been reported in less than 2% of patients. Allergic reactions including rash, urticaria, and angioedema occur rarely. Isolated cases of palpitations and tachycardia have been reported, though causal relationship remains uncertain. The incidence of side effects is generally comparable to placebo in clinical trials, demonstrating the favorable tolerability profile of this medication.
Drug interaction
Allegra demonstrates minimal cytochrome P450 metabolism, resulting in fewer pharmacokinetic interactions than many other medications. However, concomitant administration with ketoconazole or erythromycin may increase fexofenadine plasma concentrations. Antacids containing aluminum and magnesium should not be taken within 2 hours of dosing due to reduced absorption. Fruit juices (particularly apple, orange, and grapefruit) may decrease bioavailability and should be avoided around dosing time. No clinically significant interactions have been observed with warfarin, digoxin, or ethanol. However, patients should always inform healthcare providers of all concomitant medications, including over-the-counter products and herbal supplements.
Missed dose
If a dose is missed, patients should take it as soon as they remember, unless it is nearly time for the next scheduled dose. In such cases, the missed dose should be skipped and the regular dosing schedule resumed. Patients should never double the dose to make up for a missed administration. Consistency in dosing maintains stable plasma concentrations and optimal therapeutic effect. For once-daily formulations, if remembered within 12 hours of missed dose, administration is appropriate; if beyond 12 hours, wait until next scheduled dose. Healthcare providers should be consulted if multiple doses are missed or if uncertainty exists regarding proper dosing schedule.
Overdose
In case of suspected overdose, patients should seek immediate medical attention. Symptoms may include dizziness, drowsiness, and dry mouth. Doses up to 800 mg twice daily for one month have been administered without significant adverse effects in clinical studies. However, any intentional overdose requires medical evaluation. Treatment should be supportive and symptomatic, as there is no specific antidote for fexofenadine overdose. Gastric lavage may be considered if presented soon after ingestion. Hemodialysis is unlikely to be effective due to high protein binding and extensive tissue distribution. Monitoring of vital signs and ECG may be indicated in cases of substantial overdose.
Storage
Store Allegra tablets and oral suspension at room temperature between 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C to 30°C (59°F to 86°F). Protect from excessive moisture and light. Keep the bottle tightly closed and store in original container. Do not remove desiccant from packaging. Oral suspension should be used within 30 days after opening and should not be frozen. Keep all medications out of reach of children and pets. Do not use beyond the expiration date printed on packaging. Proper storage ensures maintenance of pharmaceutical stability and efficacy throughout the product’s shelf life.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Individual responses to medication may vary. Patients should consult with a qualified healthcare professional before starting or changing any treatment regimen. The prescribing physician should be informed of complete medical history, including all current medications and existing health conditions. Only a healthcare provider can determine the appropriate treatment based on individual patient needs and circumstances. This product should be used only as directed and should not be shared with others, even if they have similar symptoms.
Reviews
Clinical studies demonstrate Allegra’s efficacy with 70-80% of patients experiencing significant symptom improvement. Healthcare providers consistently rate it highly for its favorable benefit-risk profile and patient satisfaction. Patients report improved quality of life measures, particularly noting the absence of sedation compared to traditional antihistamines. Long-term studies confirm maintained efficacy with continuous use throughout allergy seasons. The medication receives consistently high marks in patient preference surveys compared to other second-generation antihistamines. Real-world evidence supports the clinical trial data, confirming effectiveness in diverse patient populations and various environmental conditions.