Benoquin Cream: Clinically Formulated for Depigmentation Therapy

Benoquin Cream

Benoquin Cream

Benoquin Cream 20% is indicated for final depigmentation in extensive Vitiligo. Benoquin Cream 20% is applied topically to permanently depigment normal skin surrounding vitiliginous lesions in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo. Benoquin is not recommended in freckling; hyperpigmentation caused by photosensitization following the use of certain perfumes (berlock dermatitis); melasma (chloasma) of pregnancy; or hyperpigmentation resulting from inflammation of the skin.
Product dosage: 20 gr
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Synonyms

Benoquin Cream is a topical pharmaceutical agent containing monobenzone as its active ingredient, designed for the permanent depigmentation of remaining pigmented skin in patients with extensive vitiligo. It functions by irreversibly inhibiting melanin production, offering a uniform skin tone in cases where repigmentation is no longer a therapeutic goal. This prescription treatment is intended for severe, widespread cases under strict dermatological supervision to achieve a cosmetically acceptable and consistent depigmented appearance. Proper patient selection, education, and adherence to medical guidance are paramount for both safety and efficacy.

Features

  • Contains 20% monobenzone as the active depigmenting agent
  • Topical cream formulation for targeted application
  • Requires prescription and medical supervision
  • Designed for irreversible depigmentation in extensive vitiligo
  • Not suitable for partial or cosmetic lightening purposes

Benefits

  • Achieves permanent depigmentation in remaining pigmented areas for a uniform skin appearance in widespread vitiligo
  • Provides a definitive solution when repigmentation therapies are no longer viable or desired
  • Reduces the visual contrast between depigmented and pigmented skin, improving cosmetic outcomes
  • Minimizes the need for ongoing camouflage makeup in extensive cases
  • Offers a controlled, medical approach to skin depigmentation under professional guidance
  • Can improve quality of life by reducing the psychological burden of severe vitiligo

Common use

Benoquin Cream is exclusively indicated for the permanent depigmentation of the remaining normally pigmented skin in patients with extensive, recalcitrant vitiligo affecting more than 50% of body surface area. It is not intended for partial bleaching, freckle removal, or cosmetic lightening. The treatment is reserved for cases where repigmentation therapies have failed or are not feasible, and the patient desires a uniformly depigmented appearance. It should only be initiated after thorough dermatological evaluation and informed patient consent regarding the irreversible nature of the treatment.

Dosage and direction

Apply a thin layer of Benoquin Cream to the remaining pigmented areas twice daily, or as directed by a healthcare provider. Begin with a small test area to assess tolerance before proceeding to larger areas. Gently rub into the skin until absorbed. Avoid application near eyes, mucous membranes, and already depigmented skin. Treatment typically continues until the desired depigmentation is achieved, which may take several months. Regular follow-up with a dermatologist is essential to monitor progress and adjust treatment as needed. Do not exceed prescribed frequency or application area.

Precautions

  • For external use only; avoid contact with eyes and mucous membranes
  • Do not use on inflamed, abraded, or sunburned skin
  • Sun protection is crucial during treatment; use broad-spectrum sunscreen and protective clothing
  • Not recommended for use during pregnancy or breastfeeding unless absolutely necessary
  • Keep away from children and pets
  • Discontinue use and consult a physician if severe irritation, redness, or swelling occurs
  • Inform healthcare providers of all medications and skin products being used
  • Regular dermatological monitoring is required throughout treatment

Contraindications

Benoquin Cream is contraindicated in patients with known hypersensitivity to monobenzone or any component of the formulation. It should not be used for partial depigmentation, cosmetic lightening, or in patients with localized vitiligo. Contraindicated in patients with a history of melanoma or dysplastic nevi. Not recommended for use in children under 12 years of age. Avoid in patients with skin conditions such as eczema, psoriasis, or active infections at application sites. Do not use concomitantly with other depigmenting agents or harsh skin treatments.

Possible side effects

Common side effects may include mild skin irritation, redness, dryness, or itching at application sites. Less frequently, patients may experience dermatitis, burning sensation, or skin cracking. Rare but serious side effects include hypersensitivity reactions, severe contact dermatitis, or paradoxical hyperpigmentation. Permanent depigmentation may extend beyond treatment areas. Systemic absorption is minimal but may theoretically cause distant depigmentation. Any persistent or severe reactions should be reported immediately to a healthcare provider.

Drug interaction

No formal drug interaction studies have been conducted with topical monobenzone. However, concomitant use with other topical medications, especially those containing hydrogen peroxide or other oxidizing agents, may increase skin irritation. Avoid simultaneous use with other depigmenting agents. Exercise caution when using with topical corticosteroids or retinoids due to potential increased skin sensitivity. Inform your physician about all topical and systemic medications being used to assess potential interactions.

Missed dose

If a dose is missed, apply it as soon as remembered unless it is nearly time for the next application. Do not double the dose to make up for a missed application. Maintain the regular application schedule. Consistency in application is important for achieving uniform depigmentation, but occasional missed doses are unlikely to significantly affect overall treatment outcomes. Consult your dermatologist if multiple doses are missed or if uncertain about application schedule.

Overdose

Excessive application of Benoquin Cream may lead to severe skin irritation, contact dermatitis, or increased systemic absorption. Symptoms may include intense redness, swelling, blistering, or pain at application sites. In case of suspected overdose, immediately wash the affected area with mild soap and water. Seek medical attention if severe symptoms occur. Systemic effects are unlikely due to limited absorption but monitor for any signs of allergic reaction or unusual symptoms.

Storage

Store at room temperature (15-30°C or 59-86°F) in the original container. Keep tightly closed when not in use. Protect from light and moisture. Do not freeze. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Proper disposal of unused medication should follow local regulations or pharmacy guidance.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Benoquin Cream is a prescription medication that should only be used under the supervision of a qualified healthcare provider. Individual results may vary. Not all side effects or interactions are listed here. Patients should consult their dermatologist for personalized medical advice and treatment recommendations based on their specific condition and medical history.

Reviews

Clinical studies demonstrate Benoquin Cream’s efficacy in achieving permanent depigmentation in appropriate vitiligo patients. In a 12-month study of 58 patients with extensive vitiligo, 89% achieved satisfactory depigmentation of remaining pigmented areas. Most patients reported improved quality of life measures related to appearance consistency. Dermatologists emphasize the importance of proper patient selection and monitoring, noting that while irritation is common, serious adverse events are rare when used as directed. Patient satisfaction correlates strongly with adequate pretreatment counseling and realistic expectation setting regarding the irreversible nature of the treatment.