Calcort: Advanced Glucocorticoid Therapy for Severe Inflammation Control
Calcort
| Product dosage: 6 mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.80 | $54.00 (0%) | 🛒 Add to cart |
| 60 | $1.60 | $108.00 $96.00 (11%) | 🛒 Add to cart |
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| 360 | $1.19
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Synonyms | |||
Calcort (deflazacort) is a potent, second-generation glucocorticoid engineered for precision anti-inflammatory and immunosuppressive action. As a prodrug, it is metabolized to its active form to deliver targeted therapeutic effects with a potentially improved tolerability profile compared to some traditional corticosteroids. It is indicated for the management of inflammatory and autoimmune conditions where high-efficacy intervention is required. Its distinct pharmacological profile supports its use in both acute exacerbations and chronic disease management, under strict medical supervision.
Features
- Active ingredient: Deflazacort, a glucocorticoid prodrug
- Available in 6 mg and 30 mg tablet formulations
- Metabolized to active 21-desacetyldeflazacort for sustained effect
- Designed for once-daily oral administration
- Manufactured under strict pharmaceutical quality controls
Benefits
- Provides potent anti-inflammatory and immunosuppressive activity to rapidly reduce swelling, pain, and disease progression
- May offer a more favorable side effect profile regarding weight gain and fluid retention compared to some other corticosteroids
- Supports functional improvement in chronic inflammatory conditions, enhancing quality of life and daily activity tolerance
- Enables flexible dosing strategies for both induction and maintenance therapy phases
- Helps reduce dependency on higher-dose or multiple immunosuppressive agents in combination therapy regimens
Common use
Calcort is commonly prescribed for a range of moderate to severe inflammatory and autoimmune disorders. These include rheumatoid arthritis, systemic lupus erythematosus, dermatological conditions such as severe psoriasis or eczema, allergic states unresponsive to conventional treatments, asthma, and certain hematologic disorders. It is also used in management protocols for certain types of nephrotic syndrome, ulcerative colitis, and other conditions where immunosuppression is clinically warranted.
Dosage and direction
Dosage must be individualized based on disease severity, patient response, and concomitant therapies. The usual initial dose ranges from 6 mg to 90 mg per day, administered orally as a single daily dose. For many chronic conditions, the initial dose is gradually tapered to the lowest effective maintenance dose. Tablets should be taken with food to minimize gastrointestinal discomfort. Dosage adjustments are necessary in patients with hepatic impairment. Always follow the precise dosing schedule prescribed by a healthcare professional; do not alter dosage without consultation.
Precautions
Patients undergoing treatment with Calcort require careful medical supervision. Regular monitoring of blood pressure, blood glucose, electrolytes, and bone density is advised. Use with caution in patients with diabetes, hypertension, osteoporosis, peptic ulcer disease, or a history of psychiatric disorders. Immunosuppression may increase susceptibility to infections; avoid exposure to contagious illnesses and report any signs of infection promptly. Live vaccines should be avoided during therapy. Long-term use may suppress adrenal function; abrupt discontinuation must be avoided.
Contraindications
Calcort is contraindicated in patients with systemic fungal infections and known hypersensitivity to deflazacort or any excipients in the formulation. It should not be administered to patients with active or latent tuberculosis, active herpes simplex keratitis, or untreated bacterial/viral/fungal systemic infections. Use is also contraindicated in patients with recent live virus vaccination. Safety during pregnancy and breastfeeding has not been fully established; use only if potential benefit justifies potential risk.
Possible side effect
Common side effects may include gastrointestinal discomfort, increased appetite, weight gain, insomnia, mood changes, and facial flushing. More serious potential adverse reactions include hyperglycemia, hypertension, fluid and electrolyte disturbances, osteoporosis, avascular necrosis, peptic ulcer, increased intraocular pressure, cataracts, and secondary adrenal suppression. Psychiatric effects such as euphoria, depression, or psychotic tendencies may occur. Long-term use can lead to cushingoid appearance, skin thinning, and easy bruising.
Drug interaction
Calcort may interact with several drug classes. Concurrent use with NSAIDs may increase risk of GI ulceration. It may diminish the effects of antihypertensives and hypoglycemic agents. Interactions with anticoagulants like warfarin may require dosage adjustment. CYP3A4 inducers (e.g., phenytoin, rifampin) may reduce deflazacort efficacy, while inhibitors may increase exposure. Use with diuretics may exacerbate electrolyte loss. Concomitant use with other immunosuppressants may increase infection risk. Always inform your physician of all medications, including over-the-counter and herbal products.
Missed dose
If a dose is missed, take it as soon as remembered on the same day. If it is near the time of the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one. Consistent dosing is important to maintain stable therapeutic effects and minimize withdrawal symptoms, especially during tapering phases.
Overdose
Acute overdose with Calcort is unlikely to produce acute life-threatening symptoms, but may exacerbate typical side effects such as hyperglycemia, hypertension, edema, or psychiatric disturbances. There is no specific antidote; treatment involves supportive care and management of symptoms. Gastric lavage may be considered if ingestion was recent. Medical attention should be sought immediately in case of suspected overdose, particularly in children or patients with comorbid conditions.
Storage
Store Calcort tablets at room temperature (15–30°C), in a dry place, protected from light and moisture. Keep the container tightly closed. Do not store in bathrooms or near sinks. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions regarding a medical condition or before starting any new treatment. Do not disregard or delay seeking professional medical advice based on content provided here. The manufacturer and publisher are not liable for any outcome resulting from the use or misuse of this information.
Reviews
Clinical studies and patient reports indicate that Calcort is effective in controlling severe inflammatory symptoms, with some patients noting less weight gain compared to prednisone. Physicians appreciate its once-daily dosing for patient compliance. However, individual responses vary, and adherence to monitoring protocols is essential to mitigate long-term risks.