Cefaclor: Effective Oral Antibiotic for Bacterial Infections
Cefaclor
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| Product dosage: 500mg | |||
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Cefaclor is a second-generation cephalosporin antibiotic designed to combat a wide spectrum of bacterial pathogens. It functions by inhibiting bacterial cell wall synthesis, leading to the eradication of susceptible organisms. This oral medication is commonly prescribed for respiratory, skin, and urinary tract infections, offering a reliable option for both community and clinical settings. Its well-established efficacy and safety profile make it a preferred choice among healthcare providers for treating common bacterial diseases.
Features
- Belongs to the cephalosporin class of antibiotics
- Available in capsule, tablet, and oral suspension formulations
- Demonstrates activity against Gram-positive and Gram-negative bacteria
- Oral bioavailability allows for convenient outpatient use
- Stable under acidic conditions, supporting effective gastrointestinal absorption
Benefits
- Rapid onset of action helps alleviate infection symptoms quickly
- Broad-spectrum coverage reduces the need for multiple antibiotics
- High efficacy rates in treating common community-acquired infections
- Well-tolerated profile with a low incidence of severe adverse effects
- Flexible dosing options accommodate both adult and pediatric patients
- Helps prevent complications from bacterial infections when used appropriately
Common use
Cefaclor is indicated for the treatment of bacterial infections caused by susceptible strains of microorganisms. Common uses include pharyngitis, tonsillitis, otitis media, acute bronchitis, pneumonia, skin and soft tissue infections, and urinary tract infections. It is particularly effective against Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, and Escherichia coli. Medical professionals may prescribe cefaclor based on culture and sensitivity results when available, or empirically when typical pathogens are suspected.
Dosage and direction
The dosage of cefaclor varies based on the infection severity, patient age, renal function, and pathogen susceptibility. For adults, the typical dose is 250-500 mg every 8 hours. For more severe infections, doses up to 1 gram every 8 hours may be administered. Pediatric dosing is typically 20-40 mg/kg/day divided into two or three doses, not to exceed 1 gram daily. The oral suspension should be shaken well before each use. Cefaclor should be taken with food to minimize gastrointestinal upset. Complete the full course of therapy even if symptoms improve earlier to prevent antibiotic resistance.
Precautions
Patients should inform their healthcare provider of any history of gastrointestinal disease, particularly colitis. Use with caution in patients with renal impairment; dosage adjustments may be necessary. Prolonged use may result in overgrowth of nonsusceptible organisms. If superinfection occurs during therapy, appropriate measures should be taken. Cefaclor should be used during pregnancy only if clearly needed and after careful risk-benefit assessment. Nursing mothers should consult their physician as cefaclor is excreted in human milk.
Contraindications
Cefaclor is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics. Cross-sensitivity may occur in patients allergic to penicillins; caution is advised in individuals with a history of beta-lactam allergy. Should not be administered to patients who have experienced previous serious hypersensitivity reactions to any cephalosporin. Not recommended for patients with a history of antibiotic-associated colitis.
Possible side effect
Common side effects may include diarrhea (2-5%), nausea (1-3%), vomiting, and abdominal pain. Hypersensitivity reactions such as rash, urticaria, and pruritus occur in approximately 1-2% of patients. Less frequently, patients may experience headache, dizziness, or reversible interstitial nephritis. Transient elevations in liver enzymes have been reported. As with most antibiotics, pseudomembranous colitis caused by Clostridium difficile may occur during or after treatment. Serious but rare adverse effects include Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis.
Drug interaction
Probenecid may decrease renal tubular secretion of cefaclor, increasing serum concentrations. Oral anticoagulants may have enhanced effects when taken concurrently with cefaclor, requiring closer monitoring of coagulation parameters. Concomitant use with nephrotoxic drugs may increase the risk of renal dysfunction. Cefaclor may cause a false-positive reaction for glucose in the urine with copper reduction tests. The antibiotic may reduce the efficacy of oral contraceptives; additional contraceptive methods are recommended during treatment.
Missed dose
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. Maintaining consistent antibiotic levels is important for therapeutic efficacy, but occasional missed doses are unlikely to significantly impact treatment outcomes if the regular schedule is promptly resumed.
Overdose
Symptoms of cefaclor overdose may include nausea, vomiting, epigastric distress, and diarrhea. In cases of significant overdose, hemodialysis may aid in removal of the drug from the bloodstream. Management should be symptomatic and supportive. There is no specific antidote for cefaclor overdose. Patients should seek immediate medical attention if a substantial overdose is suspected, particularly in children or individuals with renal impairment.
Storage
Store cefaclor capsules and tablets at room temperature (15-30°C) in a tightly closed container, protected from moisture and light. The oral suspension should be stored in the refrigerator after reconstitution and discarded after 14 days. Keep all medications out of reach of children and pets. Do not use cefaclor beyond the expiration date printed on the packaging.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before starting any new medication or treatment. The prescribing physician should be the ultimate authority regarding appropriate use, dosage, and duration of cefaclor therapy based on individual patient factors and specific clinical circumstances.
Reviews
Clinical studies demonstrate cefaclor’s efficacy rates of 85-95% for approved indications. Medical professionals appreciate its reliable spectrum of activity and generally favorable tolerability profile. Patient satisfaction surveys indicate good symptom resolution within 48-72 hours of initiation. Some reviews note gastrointestinal side effects as the most common reason for discontinuation. The oral suspension formulation receives positive feedback for its palatability in pediatric populations. Long-term clinical experience supports cefaclor’s position as a valuable antibiotic option in appropriate clinical scenarios.