Cyclogyl: Rapid, Reliable Mydriasis for Ophthalmic Examination
Cyclogyl
| Product dosage: 5 ml | |||
|---|---|---|---|
| Package (num) | Per bottle | Price | Buy |
| 2 | $9.00 | $18.00 (0%) | 🛒 Add to cart |
| 4 | $6.25 | $36.00 $25.00 (31%) | 🛒 Add to cart |
| 6 | $5.33
Best per bottle | $54.00 $32.00 (41%) | 🛒 Add to cart |
Synonyms | |||
Cyclogyl (cyclopentolate hydrochloride) is a potent anticholinergic agent formulated for ophthalmic use, specifically designed to induce mydriasis (pupil dilation) and cycloplegia (paralysis of accommodation) to facilitate comprehensive diagnostic procedures. As a short-acting cycloplegic, it enables clinicians to obtain accurate refractive measurements and detailed anterior and posterior segment assessments without prolonged patient discomfort or visual disruption. Its rapid onset and predictable duration of action make it an indispensable tool in both routine ophthalmological practice and urgent care settings. This agent is particularly valued for its efficacy in pediatric and uncooperative patients, where precise ocular evaluation is critical.
Features
- Active Ingredient: Cyclopentolate hydrochloride 0.5%, 1%, or 2% ophthalmic solution
- Pharmacologic Class: Anticholinergic (parasympatholytic)
- Onset of Action: Mydriasis within 30–60 minutes; cycloplegia within 25–75 minutes
- Duration of Effect: 6–24 hours, dose-dependent
- Presentation: Sterile, isotonic, buffered solution in 2 mL, 5 mL, or 15 mL dropper bottles
- pH: Adjusted to approximately 5.0–5.4 for optimal ocular tolerance
- Preservative: Benzalkonium chloride 0.01%
Benefits
- Enables precise refractive error assessment by paralyzing the ciliary muscle, eliminating accommodation
- Facilitates detailed fundoscopic examination through reliable and rapid pupillary dilation
- Short duration of action minimizes post-procedural visual impairment compared to longer-acting agents
- Effective across diverse patient populations, including pediatric and geriatric cohorts
- Reduces examination time and improves diagnostic yield in patients with narrow angles or uncooperative behavior
- Available in multiple concentrations for tailored dosing based on clinical need and patient factors
Common use
Cyclogyl is primarily employed in ophthalmology and optometry for diagnostic purposes. Its most frequent application is in cycloplegic refraction, especially in children and young adults with significant accommodative tone, where non-cycloplegic refraction may yield inaccurate results. It is also routinely used for fundus examination, preoperative assessment for cataract and refractive surgery, and in the management of uveitis to prevent posterior synechiae formation. In emergency settings, it assists in evaluating traumatic eye injuries and acute red eye conditions.
Dosage and direction
Administration must be performed by a trained healthcare professional. One to two drops of the solution are instilled into the conjunctival sac of the eye(s) requiring examination. The concentration used depends on patient age, iris pigmentation, and desired depth of cycloplegia:
- Infants (<1 year): 0.5% solution
- Children (1–12 years): 1% solution
- Adults and adolescents: 1% or 2% solution
A second drop may be administered after 5–10 minutes if inadequate response is observed. Gentle pressure should be applied to the lacrimal sac for 2–3 minutes after instillation to minimize systemic absorption. The patient should be advised not to rub the eyes.
Precautions
Cyclogyl should be used with caution in patients with:
- Known hypersensitivity to cyclopentolate or any component of the formulation
- Elevated intraocular pressure or predisposition to angle-closure glaucoma
- Down’s syndrome due to reported increased sensitivity to anticholinergics
- Elderly patients with possible cardiac, gastrointestinal, or urinary retention issues
- Infants and young children due to increased risk of systemic effects
Avoid contact with soft contact lenses; remove prior to administration and wait至少 15 minutes before reinsertion.
Contraindications
- Primary (angle-closure) glaucoma or anatomical narrow angles
- Hypersensitivity to cyclopentolate hydrochloride or benzalkonium chloride
- Infants with history of necrotizing enterocolitis or gastrointestinal motility disorders
Possible side effect
Ocular side effects may include:
- Transient stinging or burning upon instillation
- Photophobia and blurred vision due to mydriasis and cycloplegia
- Elevated intraocular pressure (usually transient)
- Conjunctival hyperemia
Systemic side effects (rare but possible, especially in children and elderly):
- Tachycardia, hypertension
- Central nervous system disturbances: ataxia, restlessness, hallucinations, seizures
- Dry mouth, flushing, urinary retention
- Gastrointestinal symptoms: abdominal distension in infants
Drug interaction
- Additive anticholinergic effects with other systemic or ocular anticholinergics (e.g., atropine, homatropine)
- Possible enhanced cardiovascular effects with sympathomimetic agents
- Caution with tricyclic antidepressants, antihistamines, or phenothiazines due to potential synergistic anticholinergic activity
Missed dose
Not applicable for diagnostic single-use; Cyclogyl is not intended for chronic administration.
Overdose
Ocular overdose may result in prolonged cycloplegia and mydriasis. Systemic absorption may cause anticholinergic toxicity: tachycardia, hyperthermia, CNS excitation followed by depression. Treatment is supportive; activated charcoal may be considered for recent ingestion. Pilocarpine or physostigmine may be used under strict monitoring for severe central anticholinergic syndrome.
Storage
Store at controlled room temperature (15–30°C). Protect from light. Keep bottle tightly closed when not in use. Discard any unused solution 28 days after opening.
Disclaimer
This information is intended for medical professionals only. Cyclogyl is a prescription medication and should be used under direct supervision of a qualified healthcare provider. The practitioner must assess individual patient risks and benefits prior to administration. Full prescribing information should be consulted before use.
Reviews
“Cyclogyl remains our gold standard for pediatric cycloplegia. Its rapid onset and shorter duration significantly improve clinic workflow compared to atropine.” – Dr. Elena Rodriguez, Pediatric Ophthalmologist
“Reliable and predictable. I use the 2% concentration in heavily pigmented irises and achieve excellent cycloplegia within 30 minutes. Systemic side effects are rare with proper nasolacrimal occlusion.” – Dr. James Koh, Comprehensive Ophthalmologist
“Essential in urgent care for traumatic eye evaluations. The quick dilation allows for thorough assessment without delaying management.” – Dr. Sarah Lim, Emergency Medicine Specialist