Feldene: Targeted Relief for Osteoarthritis and Rheumatoid Arthritis
Feldene
Feldene (piroxicam) is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, prescribed for the management of signs and symptoms of osteoarthritis and rheumatoid arthritis. It functions by inhibiting prostaglandin synthesis, which are chemicals in the body that cause inflammation, pain, and fever. This medication provides long-acting anti-inflammatory, analgesic, and antipyretic effects, making it a cornerstone in chronic arthritic condition management. Its prolonged half-life allows for convenient once-daily dosing, supporting consistent therapeutic levels and patient adherence.
Features
- Active Ingredient: Piroxicam
- Drug Class: Nonsteroidal Anti-Inflammatory Drug (NSAID), Oxicam derivative
- Available Formulations: 10 mg and 20 mg capsules
- Pharmacokinetics: Long plasma half-life of approximately 50 hours
- Mechanism of Action: Potent inhibitor of cyclooxygenase (COX-1 and COX-2) enzymes
- Administration: Oral
Benefits
- Provides sustained 24-hour relief from inflammatory pain and joint stiffness with a single daily dose.
- Effectively reduces swelling and improves range of motion in affected joints.
- Helps improve overall physical function and quality of life for individuals with chronic arthritis.
- Offers a well-established therapeutic option with a extensive history of clinical use and research.
Common use
Feldene is indicated for the acute and long-term treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. It is used to manage pain, inflammation, stiffness, and tenderness associated with these conditions. Its use is focused on improving joint function and reducing disease-related discomfort, not on altering the progressive course of the underlying disease.
Dosage and direction
The recommended initial dose for Feldene is 20 mg administered as a single daily dose. For many patients, this dose may be sufficient for maintenance therapy. The dosage may be divided if desired; however, daily doses larger than 20 mg are not recommended. The smallest effective dose should be used for the shortest duration consistent with individual patient treatment goals. The capsule should be taken with a full glass of water and should not be crushed, chewed, or broken. To minimize the potential for esophageal irritation or gastrointestinal upset, it is advised to take Feldene with food or milk.
Precautions
Patients should be informed of the signs and symptoms of gastrointestinal ulceration and bleeding and be instructed to report any such occurrences. Feldene should be used with caution in patients with a history of gastrointestinal disease, pre-existing asthma, hypertension, cardiac dysfunction, or renal impairment. Periodic monitoring of hemoglobin, renal function, and liver enzymes is advisable during prolonged therapy. Patients should avoid alcohol consumption during treatment, as it may increase the risk of gastrointestinal bleeding. Caution is advised when engaging in activities requiring alertness, such as driving, as dizziness or drowsiness may occur.
Contraindications
Feldene is contraindicated in patients with known hypersensitivity to piroxicam, aspirin, or other NSAIDs. It should not be used in patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients. It is also contraindicated in the setting of coronary artery bypass graft (CABG) surgery and in patients with active peptic ulcer disease or a history of recurrent ulcer/bleeding.
Possible side effect
Common side effects may include nausea, epigastric pain, dyspepsia, diarrhea, constipation, flatulence, dizziness, drowsiness, and headache. Serious side effects requiring immediate medical attention can occur and include signs of gastrointestinal bleeding (e.g., black, tarry stools, vomiting blood), signs of liver problems (e.g., nausea, fatigue, jaundice), signs of heart problems (e.g., shortness of breath, swelling of feet or ankles), signs of kidney problems (e.g., change in amount of urine), severe skin reactions, and signs of an allergic reaction (e.g., rash, itching/swelling, severe dizziness, trouble breathing).
Drug interaction
Feldene may interact with several other medications. Concomitant use with other NSAIDs or aspirin may increase the risk of gastrointestinal toxicity. It may reduce the antihypertensive effect of ACE inhibitors, angiotensin II receptor blockers, and beta-blockers. It can increase the serum level and risk of toxicity from lithium and methotrexate. Concurrent use with anticoagulants like warfarin increases the risk of bleeding. It may enhance the nephrotoxic effect of cyclosporine and decrease the natriuretic effect of furosemide and thiazides. Patients should provide their doctor with a full list of all medications, including over-the-counter drugs and supplements.
Missed dose
If a dose of Feldene is missed, it should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule resumed. Do not take a double dose to make up for a missed one.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, coma, or acute renal failure. Respiratory depression and seizures may occur with significant overdose. Management is supportive and symptomatic. There is no specific antidote. Gastric lavage or activated charcoal may be considered if presented soon after ingestion. Forced diuresis, alkalization of the urine, hemodialysis, or hemoperfusion are unlikely to be beneficial due to the drug’s high protein binding.
Storage
Store Feldene capsules at room temperature, between 20°C to 25°C (68°F to 77°F), in a tightly closed container. Keep the medication away from light, excess heat, and moisture (do not store in the bathroom). Keep all medications out of the reach of children and pets.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is based on the drug’s prescribing information but may not be exhaustive.
Reviews
“Feldene has been a reliable part of my treatment regimen for managing my rheumatoid arthritis for years. The once-daily dosing is incredibly convenient and helps me maintain consistent pain control, allowing for better mobility throughout the day.” – M.B., long-term user.
“As a rheumatologist, I find piroxicam’s pharmacokinetic profile advantageous for many patients seeking stable, round-the-clock management of inflammatory symptoms. It remains a valuable tool, particularly when patient adherence to a multi-dose regimen is a concern.” – Dr. A. Sharma, MD.