Flagyl ER: Effective Extended-Release Treatment for Bacterial Infections
Flagyl ER
| Product dosage: 200mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 120 | $0.37 | $44.00 (0%) | 🛒 Add to cart |
| 180 | $0.31 | $66.00 $56.00 (15%) | 🛒 Add to cart |
| 270 | $0.28 | $99.00 $75.00 (24%) | 🛒 Add to cart |
| 360 | $0.26
Best per pill | $132.00 $93.00 (30%) | 🛒 Add to cart |
Flagyl ER (metronidazole extended-release) is a prescription antimicrobial medication designed to provide sustained, effective therapy for a range of serious anaerobic bacterial and protozoal infections. Its advanced extended-release formulation ensures consistent drug levels, enhancing therapeutic outcomes while potentially improving patient adherence. This medication is specifically indicated for the treatment of bacterial vaginosis in adult women and is valued in clinical practice for its targeted antibacterial and antiprotozoal properties. Proper diagnosis and medical supervision are essential for its safe and effective use.
Features
- Contains 750 mg metronidazole in an extended-release tablet formulation
- Designed for once-daily dosing to maintain steady plasma concentrations
- Film-coated tablet for ease of administration
- Requires prescription and medical supervision
- Manufactured under strict pharmaceutical quality standards
Benefits
- Provides sustained release of metronidazole for consistent therapeutic effect
- Reduces dosing frequency compared to immediate-release formulations
- Effectively treats anaerobic bacterial infections and certain protozoal infections
- Clinically proven efficacy for bacterial vaginosis treatment
- May improve patient compliance due to simplified dosing schedule
- Targeted action against susceptible microorganisms with well-established efficacy profile
Common use
Flagyl ER is primarily prescribed for the treatment of bacterial vaginosis in non-pregnant adult women. It may also be used off-label for other anaerobic bacterial infections when extended-release metronidazole therapy is appropriate, though such use requires careful medical evaluation. The medication is specifically formulated for conditions where sustained metronidazole delivery is beneficial, particularly for infections caused by susceptible anaerobic bacteria including Bacteroides species, Clostridium species, and other anaerobic pathogens.
Dosage and direction
The recommended dosage for bacterial vaginosis is one 750 mg extended-release tablet taken orally once daily for seven consecutive days. Tablets should be swallowed whole with a full glass of water, without chewing, crushing, or splitting. Administration with food may help minimize gastrointestinal discomfort. Treatment should be completed in full as prescribed, even if symptoms improve before finishing the course. Dosage adjustments may be necessary for patients with hepatic impairment, though specific recommendations should be determined by a healthcare provider.
Precautions
Patients should avoid alcoholic beverages and alcohol-containing products during treatment and for at least 72 hours after completing therapy due to the risk of disulfiram-like reaction. Use with caution in patients with central nervous system diseases, blood dyscrasias, or hepatic impairment. Regular monitoring of blood counts may be advisable during prolonged therapy. Patients should report any neurological symptoms such as numbness, tingling, or seizures promptly. The medication may cause dizziness or lightheadedness, affecting ability to drive or operate machinery.
Contraindications
Flagyl ER is contraindicated in patients with known hypersensitivity to metronidazole, other nitroimidazole derivatives, or any component of the formulation. It should not be used during the first trimester of pregnancy unless clearly needed and benefits outweigh risks. Concomitant use with disulfiram is contraindicated. The medication is not recommended for patients with active neurological disorders or severe hepatic impairment without careful risk-benefit assessment.
Possible side effect
Common adverse reactions may include nausea, headache, metallic taste, anorexia, and gastrointestinal discomfort. Less frequently reported effects include dizziness, dry mouth, and darkening of urine. Serious but rare side effects may include peripheral neuropathy, seizures, encephalopathy, leukopenia, and pancreatitis. Allergic reactions ranging from skin rash to anaphylaxis may occur. Patients should contact their healthcare provider if any severe or persistent side effects develop.
Drug interaction
Significant interactions may occur with warfarin (potentiated anticoagulant effect), lithium (increased lithium levels), and disulfiram (psychotic reactions). Concurrent use with alcohol may cause disulfiram-like reaction. Metronidazole may increase levels of phenytoin, phenobarbital, and cyclosporine. Cimetidine may increase metronidazole concentrations, while phenytoin may decrease them. Patients should inform healthcare providers of all medications, including over-the-counter drugs and supplements.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed tablet. Maintaining consistent dosing intervals is important for therapeutic effectiveness. Patients should contact their healthcare provider if multiple doses are missed for guidance on resuming therapy.
Overdose
Symptoms of overdose may include nausea, vomiting, ataxia, and neurological symptoms. Severe overdose may lead to seizures or peripheral neuropathy. There is no specific antidote for metronidazole overdose. Treatment is supportive and symptomatic, including gastric lavage if ingestion was recent. Hemodialysis may accelerate elimination. In case of suspected overdose, seek immediate medical attention or contact a poison control center.
Storage
Store at controlled room temperature between 20°C to 25°C (68°F to 77°F). Protect from light and moisture. Keep in the original container with the lid tightly closed. Do not store in bathroom cabinets where moisture levels may vary. Keep out of reach of children and pets. Properly dispose of any expired or unused medication according to local regulations.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Flagyl ER is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual response to treatment may vary. Patients should consult their healthcare provider for diagnosis, treatment recommendations, and complete prescribing information. Never initiate or discontinue medication without professional medical guidance.
Reviews
Clinical studies demonstrate Flagyl ER’s efficacy in treating bacterial vaginosis with complete resolution rates comparable to immediate-release formulations. Healthcare providers note the convenience of once-daily dosing and generally favorable patient tolerance when used as directed. Some patients report preference for the extended-release formulation due to reduced dosing frequency and potentially decreased peak-related side effects. Medical literature supports metronidazole’s established role in antimicrobial therapy, with the extended-release formulation offering additional dosing flexibility in appropriate clinical scenarios.