Floxin: Potent Fluoroquinolone for Severe Bacterial Infections
Floxin
| Product dosage: 200mg | |||
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Floxin (ofloxacin) is a broad-spectrum fluoroquinolone antibiotic designed to combat serious bacterial infections with precision and efficacy. As a second-generation fluoroquinolone, it demonstrates potent bactericidal activity against both Gram-positive and Gram-negative pathogens through inhibition of bacterial DNA gyrase and topoisomerase IV. Clinically validated for treating complicated urinary tract infections, respiratory infections, and sexually transmitted diseases, Floxin offers healthcare providers a reliable therapeutic option when narrower-spectrum antibiotics prove insufficient. Its favorable pharmacokinetic profile ensures adequate tissue penetration and predictable serum concentrations.
Features
- Active ingredient: Ofloxacin 200mg/400mg tablets
- Mechanism: DNA gyrase and topoisomerase IV inhibition
- Spectrum: Broad coverage against Gram-positive and Gram-negative bacteria
- Bioavailability: Approximately 98% oral absorption
- Half-life: 4-8 hours permitting twice-daily dosing
- Excretion: Primarily renal (80-90% unchanged)
Benefits
- Rapid bactericidal action against resistant pathogens
- Excellent tissue penetration in prostate, lungs, and genitourinary tract
- Convenient twice-daily dosing regimen enhances compliance
- Demonstrated efficacy in complicated infections
- Oral formulation avoids intravenous administration in many cases
- Cost-effective alternative to newer broad-spectrum antibiotics
Common use
Floxin is indicated for the treatment of adults with complicated urinary tract infections including pyelonephritis caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and other susceptible organisms. It is also approved for community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, uncomplicated skin and skin structure infections, and sexually transmitted diseases including cervicitis/urethritis caused by Chlamydia trachomatis. Off-label uses include prostatitis, traveler’s diarrhea, and certain orthopedic infections when susceptibility is confirmed.
Dosage and direction
The recommended dosage for most infections is 400mg orally twice daily for 7-14 days. For uncomplicated urinary tract infections: 200mg twice daily for 3-7 days. For gonorrhea: single 400mg dose. Administer tablets with a full glass of water, preferably 2 hours before or 2 hours after meals. Dosage adjustment is required in renal impairment (CrCl <50 mL/min): 400mg loading dose followed by 200mg every 24 hours. Do not crush or chew tablets. Complete the full course of therapy even if symptoms improve earlier.
Precautions
Monitor patients for tendon inflammation or rupture, particularly in elderly patients, those receiving corticosteroid therapy, and organ transplant recipients. Avoid excessive sunlight exposure due to photosensitivity risk. Use with caution in patients with CNS disorders (e.g., epilepsy) due to potential seizure threshold lowering. Periodic renal function assessment recommended during prolonged therapy. May cause dizziness or lightheadedness - caution patients about driving or operating machinery. Diabetic patients should monitor blood glucose carefully due to potential hypoglycemic effects.
Contraindications
Hypersensitivity to ofloxacin, other quinolones, or any component of the formulation. Concomitant administration with tizanidine due to potentially fatal hypotension. History of tendon disorders related to quinolone use. Not recommended during pregnancy (Category C) or breastfeeding due to potential arthropathy in developing joints. Pediatric patients (except where no alternative exists for specific serious infections). Patients with known QTc prolongation or concurrent use of other QTc-prolonging medications.
Possible side effect
Common (≥1%): nausea, diarrhea, headache, dizziness, insomnia. Less common: photosensitivity reactions, tendon pain, vaginal candidiasis, elevated liver enzymes. Rare but serious: tendon rupture, peripheral neuropathy, CNS effects (seizures, psychosis), Clostridium difficile-associated diarrhea, hypoglycemia, QTc prolongation, hepatotoxicity. Discontinue immediately at first sign of tendon pain, neurological symptoms, or severe hypersensitivity reaction. Most side effects are reversible upon discontinuation.
Drug interaction
Antacids containing magnesium/aluminum, sucralfate, iron preparations: reduce absorption (administer Floxin 2 hours before or 4 hours after). Warfarin: may enhance anticoagulant effect (monitor INR closely). NSAIDs: may increase CNS stimulation risk. Corticosteroids: increased tendon rupture risk. Oral hypoglycemics: may enhance hypoglycemic effect. Probenecid: reduces renal clearance of ofloxacin. QTc-prolonging agents (antiarrhythmics, antipsychotics, macrolides): additive effect on cardiac repolarization.
Missed dose
Take the missed dose as soon as remembered, unless it is almost time for the next scheduled dose. Do not double the dose to make up for a missed one. Maintain the regular dosing schedule. If multiple doses are missed, contact healthcare provider for guidance on resuming therapy. Consistent antibiotic levels are crucial for effective bacterial eradication and prevention of resistance development.
Overdose
Symptoms may include nausea, vomiting, dizziness, headache, and confusion. CNS stimulation including seizures may occur with massive overdose. Management is supportive with ECG monitoring for QTc prolongation. Hemodialysis removes approximately 20-30% of circulating ofloxacin. Maintain adequate hydration. There is no specific antidote. Contact poison control center (1-800-222-1222) for latest management recommendations.
Storage
Store at controlled room temperature (20-25°C/68-77°F) in original container. Protect from light and moisture. Keep tightly closed. Do not store in bathroom medicine cabinet due to humidity fluctuations. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Properly discard any unused medication after completion of therapy.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Prescription antibiotics require proper diagnosis and professional medical supervision. Self-medication with antibiotics contributes to antimicrobial resistance. Always complete the full prescribed course unless directed otherwise by your healthcare provider. Report any adverse reactions to your physician and the FDA MedWatch program.
Reviews
Clinical studies demonstrate Floxin achieves clinical cure rates of 85-92% in complicated urinary tract infections and 85-90% in respiratory infections. Microbiological eradication rates typically range from 87-94% for common uropathogens. In comparative trials, ofloxacin shows equivalent efficacy to other fluoroquinolones with similar safety profiles. Post-marketing surveillance confirms the benefit-risk ratio remains favorable when used appropriately for indicated infections. Patient satisfaction surveys indicate preference for twice-daily dosing compared to more frequent regimens.