Glycomet: Advanced Blood Glucose Control for Type 2 Diabetes
Glycomet
| Product dosage: 500mg | |||
|---|---|---|---|
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| 360 | $0.20
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Glycomet (metformin hydrochloride) is a first-line oral antidiabetic medication specifically formulated for the management of type 2 diabetes mellitus. As a biguanide-class drug, it works primarily by decreasing hepatic glucose production and improving insulin sensitivity in peripheral tissues, offering a foundational approach to glycemic regulation. It is widely prescribed both as monotherapy and in combination with other antidiabetic agents, supported by extensive clinical evidence and decades of trusted use in the medical community. This product is indicated for patients seeking a reliable, evidence-based pharmacological strategy to achieve and maintain target blood glucose levels.
Features
- Active ingredient: Metformin Hydrochloride
- Available in immediate-release (IR) and extended-release (XR) tablet formulations
- Standard strengths: 500 mg, 850 mg, and 1000 mg tablets
- Mechanism: Reduces hepatic gluconeogenesis and enhances peripheral glucose uptake
- Non-hypoglycemic mechanism when used as monotherapy
- Often used in combination therapy with sulfonylureas, DPP-4 inhibitors, or insulin
Benefits
- Effectively lowers both fasting and postprandial blood glucose levels
- Associated with weight neutrality or modest weight loss, unlike some other antidiabetic agents
- May improve lipid profiles by reducing triglycerides and LDL cholesterol
- Demonstrates cardiovascular protective benefits in long-term use
- Does not typically cause hypoglycemia when used alone
- Cost-effective and widely accessible treatment option
Common use
Glycomet is primarily indicated for the management of hyperglycemia in type 2 diabetes mellitus. It is used in adult patients as an adjunct to diet and exercise. It may also be used off-label for conditions such as polycystic ovary syndrome (PCOS) due to its insulin-sensitizing effects, and occasionally for the prevention of diabetes in high-risk individuals, though such use requires specific medical supervision.
Dosage and direction
Dosage must be individualized based on effectiveness and tolerance, while not exceeding the maximum recommended daily dose.
- Initial dose: Usually 500 mg orally twice daily or 850 mg once daily, with meals.
- Maintenance dose: May be increased gradually, typically at weekly intervals, by 500 mg weekly or 850 mg every two weeks.
- Maximum dose: 2000 mg per day administered in divided doses. Some patients may tolerate up to 2550 mg per day.
- Extended-release tablets: Usually started at 500 mg once daily with the evening meal, may be increased weekly by 500 mg up to a maximum of 2000 mg once daily.
- Always take with food to reduce gastrointestinal upset.
Precautions
- Periodic monitoring of renal function is recommended; use with caution in elderly patients and those with conditions that may impair renal function.
- Avoid use in conditions associated with hypoxemia or dehydration due to increased risk of lactic acidosis.
- Temporarily discontinue prior to radiologic studies involving intravascular iodinated contrast materials.
- Vitamin B12 levels should be monitored periodically with long-term therapy.
- Not recommended during pregnancy unless clearly needed; consult an endocrinologist for alternative insulin therapy during gestation.
Contraindications
- Hypersensitivity to metformin or any component of the formulation.
- Severe renal impairment (eGFR below 30 mL/min/1.73m²).
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
- History of lactic acidosis.
- Acute congestive heart failure requiring pharmacological treatment.
Possible side effect
Common side effects are generally gastrointestinal and often transient:
- Nausea, vomiting
- Diarrhea
- Abdominal discomfort
- Flatulence
- Asthenia
- Uncommon but serious: lactic acidosis (symptoms include malaise, myalgia, respiratory distress); signs of vitamin B12 deficiency (e.g., megaloblastic anemia).
Drug interaction
- Alcohol: Potentiates the effect of metformin on lactate metabolism; avoid excessive intake.
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin): May compete for renal tubular secretion and increase metformin levels.
- Glucocorticoids, diuretics, sympathomimetics may reduce hypoglycemic effect.
- Iodinated contrast agents: May alter renal function; temporarily discontinue metformin.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one.
Overdose
Hypoglycemia has not been seen with acute overdoses of metformin alone, but lactic acidosis may occur. Symptoms may include extreme weakness, nausea, vomiting, hyperventilation. Hemodialysis may remove metformin and correct acidosis. Seek immediate medical attention.
Storage
Store at controlled room temperature (20–25°C). Keep container tightly closed. Protect from moisture and light. Keep out of reach of children.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and individualized dosing. Do not initiate or discontinue therapy without medical supervision.
Reviews
Glycomet is consistently rated among the most effective and well-tolerated first-line treatments for type 2 diabetes in clinical practice. Physicians appreciate its efficacy, safety profile, and metabolic benefits beyond glycemic control. Patients often report improved quality of life and glycemic stability, though some note initial gastrointestinal side effects that typically subside with continued use. Long-term users highlight the importance of adherence and regular monitoring for optimal outcomes.