Poxet: Clinically Proven Premature Ejaculation Management
Poxet
| Product dosage: 60mg | |||
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Premature ejaculation (PE) is a prevalent male sexual health concern, impacting a significant portion of the adult male population and often leading to distress, relationship strain, and diminished self-confidence. Poxet represents a targeted pharmacological intervention designed to address the underlying neurobiological mechanisms of this condition. This dapoxetine hydrochloride-based treatment is specifically formulated for on-demand use, offering a scientifically-backed solution to prolong intravaginal ejaculatory latency time (IELT). By selectively inhibiting serotonin reuptake, Poxet helps restore control and significantly improve sexual satisfaction for men and their partners, facilitating a more fulfilling intimate experience.
Features
- Active Pharmaceutical Ingredient: Dapoxetine Hydrochloride.
- Available Dosage Strengths: 30 mg and 60 mg film-coated tablets.
- Pharmacological Class: Selective Serotonin Reuptake Inhibitor (SSRI).
- Administration: Oral, on-demand (prn) use.
- Rapid Onset of Action: Designed to be taken 1-3 hours prior to anticipated sexual activity.
- Short Elimination Half-Life: Optimized for intermittent use, minimizing long-term accumulation.
- Manufactured in cGMP-compliant facilities ensuring purity and consistent potency.
Benefits
- Significantly Prolongs Ejaculatory Latency: Clinical studies demonstrate a 2.5 to 3-fold increase in average IELT, providing tangible, measurable improvement.
- Enhances Perceived Control Over Ejaculation: Users report a substantial increase in confidence and a greater sense of command during sexual activity.
- Improves Sexual Satisfaction: For both the patient and their partner, leading to reduced personal and interpersonal distress associated with PE.
- On-Demand Dosing Flexibility: Does not require daily administration, allowing for treatment only when needed and aligning with natural sexual spontaneity.
- Evidence-Based Efficacy: Formulated based on extensive clinical research and understanding of the serotonergic control of ejaculation.
Common use
Poxet (dapoxetine) is indicated for the treatment of premature ejaculation (PE) in adult men aged 18 to 64 years. It is prescribed for men who meet the diagnostic criteria for PE, which typically includes: persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it; this condition must cause marked distress or interpersonal difficulty; and the dysfunction is not due exclusively to the direct effects of a substance or a general medical condition. It is used on an as-needed basis to manage these symptoms.
Dosage and direction
The recommended starting dose for all patients is 30 mg, taken orally as a single dose approximately 1 to 3 hours prior to anticipated sexual activity. It may be taken with or without food. Based on efficacy and tolerability, the dose may be increased to the maximum recommended dose of 60 mg. Poxet is not intended for daily use. Administration should not be repeated within a 24-hour period. The tablet should be swallowed whole with a full glass of water; it should not be divided, crushed, or chewed. It is crucial to follow the specific dosage instructions provided by the prescribing healthcare professional.
Precautions
- Orthostatic Hypotension: Dapoxetine is associated with orthostatic hypotension (a drop in blood pressure upon standing). Patients should be cautious when moving from a sitting or lying down position to standing.
- Syncope (Fainting): There is a risk of syncope; patients should be in a safe setting, especially after the first dose or after a dose increase.
- Mood Changes: As with other SSRIs, monitor for the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania. Patients with a history of bipolar disorder are at greater risk.
- Withdrawal: While the risk is lower due to its short half-life, abrupt discontinuation can potentially lead to dizziness, nausea, irritability, and sleep disturbances.
- Priapism: Although rare, prolonged and painful erections lasting more than 4 hours have been reported with this class of drugs and require immediate medical attention to prevent permanent damage.
- Elderly Patients: Safety and efficacy in patients over 65 have not been established. Use is not recommended.
- Underlying Cardiovascular Disease: Patients should be evaluated for underlying cardiovascular disease before initiating treatment.
Contraindications
Poxet is contraindicated in patients with:
- Known hypersensitivity to dapoxetine or any of the excipients in the formulation.
- Significant pathological cardiac conditions such as heart failure (NYHA Class II-IV), conduction abnormalities (e.g., sick sinus syndrome, sinoatrial or AV block), significant ischemic heart disease, or valvular disease.
- History of syncope.
- Concomitant administration with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy. Similarly, MAOIs should not be initiated within 7 days of discontinuing Poxet.
- Concomitant administration with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin, telithromycin).
- Concomitant administration with thioridazine, or within 4 weeks of discontinuing thioridazine therapy.
- Concomitant administration with other serotonergic drugs (e.g., SSRIs, SNRIs, triptans, tramadol, lithium, St. John’s Wort) due to the increased risk of serotonin syndrome.
- Severe hepatic impairment (Child-Pugh Class C).
Possible side effect
Like all medicines, Poxet can cause side effects, although not everybody gets them. The most common side effects are usually mild to moderate and often diminish with continued use. They include:
- Very Common (≥1/10): Headache, dizziness, nausea.
- Common (≥1/100 to <1/10): Diarrhea, insomnia, somnolence (sleepiness), fatigue, anxiety, tremors, blurred vision, vomiting, abdominal pain, dry mouth, hyperhidrosis (increased sweating), flushing.
- Uncommon (≥1/1,000 to <1/100): Syncope (fainting), tachycardia (increased heart rate), palpitations, erectile dysfunction, decreased libido, anxiety, agitation, confusion, paresthesia (tingling sensation), tinnitus, dyspepsia, flatulence, rash, pruritus (itching), chills, irritability, abnormal dreams, tension.
- Rare (<1/1,000): Orthostatic hypotension, hypotension, hypertension, euphoric mood, aggression, depersonalization, mania, suicidal ideation, angle-closure glaucoma, urinary retention.
Drug interaction
Poxet has the potential for significant drug interactions:
- Strong CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin): Contraindicated. These drugs significantly increase dapoxetine plasma levels, increasing the risk of adverse effects.
- Moderate CYP3A4 Inhibitors (e.g., erythromycin, fluconazole, diltiazem): Concomitant use is not recommended. A dose reduction to 30 mg may be considered if combined cautiously.
- CYP2D6 Inhibitors (e.g., fluoxetine, paroxetine): May increase dapoxetine exposure. Maximum dose should not exceed 30 mg if used concomitantly.
- Serotonergic Drugs (other SSRIs, SNRIs, triptans, tramadol, lithium, tryptophan, St. John’s Wort): Increased risk of serotonin syndrome (symptoms include agitation, hallucinations, coma, tachycardia, labile blood pressure, hyperthermia, incoordination, nausea, vomiting, diarrhea).
- Alcohol: Concomitant use with alcohol may increase the risk of adverse events such as dizziness, drowsiness, and decreased alertness. It may also increase cardiovascular effects. Patients should avoid alcohol while taking Poxet.
- Alpha-adrenergic blockers (e.g., tamsulosin): May potentially increase the risk of orthostatic hypotension and syncope.
- Phenytoin: May decrease dapoxetine concentrations.
Missed dose
Poxet is not taken on a daily schedule. It is taken only as needed, approximately 1-3 hours before anticipated sexual activity. Therefore, the concept of a “missed dose” does not apply. Do not take a double dose to make up for a missed opportunity.
Overdose
In case of overdose, supportive measures should be instituted. Symptoms of overdose are expected to be an extension of the adverse reactions profile, including serotonergic effects such as serotonin syndrome (agitation, confusion, diaphoresis, tachycardia, hyperthermia), dizziness, nausea, vomiting, and syncope. There is no specific antidote for dapoxetine overdose. Treatment should consist of general supportive measures, including monitoring of vital signs and ECG. Gastric lavage may be considered if performed soon after ingestion. Activated charcoal may also be useful. Forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit due to the high protein binding and large volume of distribution of dapoxetine.
Storage
- Store below 30°C (86°F).
- Keep the blister strips in the outer carton to protect from light and moisture.
- Keep out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the carton and blister after “EXP”.
- Do not dispose of medications via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The information provided is not exhaustive and may not cover all possible uses, directions, precautions, interactions, or adverse effects.
Reviews
- Dr. A. Sharma, Urologist: “In my practice, Poxet has been a valuable tool for managing primary premature ejaculation. The on-demand nature is a significant advantage over daily SSRIs, and most of my patients report a meaningful improvement in IELT and sexual satisfaction with a manageable side effect profile when dosed appropriately.”
- Clinical Study Participant, Phase III Trial: “The difference was noticeable from the first use. It gave me the control I had been lacking for years. The side effects were present initially (some dizziness and mild nausea) but faded after a few uses. It has positively impacted my relationship.”
- M.B., 42: “After trying behavioral techniques with limited success, my doctor recommended Poxet. It works as described. Taking it about 90 minutes beforehand is the sweet spot for me. It’s not a magic pill, but it provides the window of opportunity to focus on pleasure rather than performance anxiety.”
- Dr. E. Lopez, Psychiatrist: “While effective, it is crucial to screen patients for underlying mood disorders. I have seen cases where it exacerbated underlying anxiety. It should be part of a comprehensive treatment plan that may include psychological counseling for best long-term outcomes.”