Prothiaden: Effective Relief for Depression and Anxiety Disorders
Prothiaden
| Product dosage: 75 mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.97 | $58.00 (0%) | 🛒 Add to cart |
| 90 | $0.89 | $87.00 $80.00 (8%) | 🛒 Add to cart |
| 120 | $0.77 | $116.00 $92.00 (21%) | 🛒 Add to cart |
| 180 | $0.73
Best per pill | $174.00 $131.00 (25%) | 🛒 Add to cart |
Synonyms | |||
Prothiaden (dothiepin hydrochloride) is a tricyclic antidepressant (TCA) indicated for the management of major depressive disorder and certain anxiety conditions. With a well-established efficacy profile supported by decades of clinical use, it functions primarily by inhibiting the reuptake of serotonin and norepinephrine, thereby restoring neurotransmitter balance in the central nervous system. Its sedative properties make it particularly suitable for patients experiencing prominent insomnia or agitation alongside depressive symptoms. Available in tablet form, Prothiaden offers a trusted option within its therapeutic class for appropriate patient populations under specialist supervision.
Features
- Active ingredient: Dothiepin hydrochloride
- Available in 25 mg and 75 mg tablet strengths
- Dual mechanism: serotonin and norepinephrine reuptake inhibition
- Notable sedative effect, beneficial for sleep disturbances in depression
- Long half-life allowing for once-daily dosing in maintenance therapy
- Film-coated tablets for ease of swallowing
Benefits
- Effectively alleviates core symptoms of moderate to severe depression
- Reduces anxiety and somatic complaints often associated with depressive disorders
- Improves sleep architecture and reduces latency to sleep onset
- Provides balanced neurotransmitter modulation with a single agent
- Supports functional recovery and improves overall quality of life
- Established long-term safety profile when used as directed
Common use
Prothiaden is primarily prescribed for the treatment of major depressive episodes. It is also used off-label in certain anxiety disorders, neuropathic pain conditions, and as an adjunct in severe insomnia where depression is comorbid. Its use is generally reserved for cases where first-line antidepressants such as SSRIs have been ineffective or poorly tolerated, or where sedation is desired as part of the therapeutic effect.
Dosage and direction
Initial dosing for depression in adults typically begins at 75 mg daily, usually administered as a single dose at bedtime. This may be increased gradually under medical supervision to a maximum of 150 mg daily, based on therapeutic response and tolerability. Elderly patients or those with hepatic impairment should start at a lower dose, often 25–50 mg daily. Tablets should be swallowed whole with water and can be taken with or without food. Abrupt discontinuation should be avoided; dose tapering is recommended under clinical guidance.
Precautions
Patients should be monitored for worsening depression, suicidality, or unusual changes in behavior, especially during the initial weeks of therapy or after dose adjustments. Caution is advised in patients with cardiovascular disease, glaucoma, urinary retention, or a history of seizures. Prothiaden may impair alertness; patients should avoid driving or operating machinery until their response is known. Regular liver function tests and blood counts may be advised during prolonged therapy.
Contraindications
Prothiaden is contraindicated in patients with known hypersensitivity to dothiepin or other tricyclic antidepressants. It must not be used concomitantly with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy. Additional contraindications include recent myocardial infarction, severe liver disease, and narrow-angle glaucoma. It is not recommended during pregnancy or breastfeeding unless clearly necessary and under strict medical supervision.
Possible side effects
Common side effects may include drowsiness, dry mouth, constipation, blurred vision, and dizziness. Less frequently, patients may experience orthostatic hypotension, weight gain, sweating, or urinary retention. Serious side effects such as cardiac arrhythmias, seizures, or significant blood dyscrasias are rare but require immediate medical attention. Most adverse effects are dose-dependent and may diminish over time.
Drug interactions
Prothiaden may interact with CNS depressants (e.g., alcohol, benzodiazepines), antihypertensives, anticholinergics, and serotonergic agents (including SSRIs and tramadol), increasing the risk of serotonin syndrome. Concomitant use with other drugs that prolong the QT interval should be avoided. It may also potentiate the effects of warfarin and other anticoagulants. A comprehensive medication review is essential before initiation.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Doubling the dose to compensate for a missed one is not recommended.
Overdose
Overdose of Prothiaden can be severe and potentially fatal. Symptoms may include extreme drowsiness, agitation, confusion, tachycardia, hypotension, convulsions, and cardiac arrhythmias. Management is supportive and may include gastric lavage, activated charcoal, and symptomatic treatment. ECG monitoring is essential. Specialist toxicology support should be sought immediately.
Storage
Store at room temperature (15–30°C) in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is intended for healthcare professionals and educated patients and should not replace personalized medical advice. Always consult a qualified physician for diagnosis, treatment decisions, and individualized dosing. Use only as prescribed.
Reviews
Clinical studies and post-marketing surveillance indicate that Prothiaden is effective in reducing depressive and anxiety symptoms, particularly in patients with sleep disturbances. Some reviews note its tolerability profile as acceptable compared to other TCAs, though sedation and anticholinergic effects may limit use in some individuals. Long-term users often report sustained symptomatic relief when adherence is maintained under regular review.