Voveran SR: Sustained Relief for Chronic Pain and Inflammation
Voveran
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Synonyms | |||
Voveran SR (diclofenac sodium) is a nonsteroidal anti-inflammatory drug (NSAID) formulated for sustained release, offering prolonged therapeutic action for managing moderate to severe pain and inflammatory conditions. Its advanced delivery system ensures steady plasma concentrations, reducing dosing frequency while maintaining efficacy. This makes it a preferred choice for long-term management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, providing consistent symptom control and improved patient compliance.
Features
- Active ingredient: Diclofenac sodium 100 mg
- Pharmaceutical form: Sustained-release tablet
- Mechanism: Cyclooxygenase (COX) inhibition, reducing prostaglandin synthesis
- Duration: 24-hour controlled release for stable pharmacokinetics
- Coating: Enteric-coated to minimize gastric irritation
- Bioavailability: Approximately 50–60% due to first-pass metabolism
- Half-life: 12–15 hours in sustained-release formulation
Benefits
- Provides continuous, around-the-clock relief from pain and inflammation, reducing breakthrough symptoms
- Minimizes dosing frequency to once daily, enhancing adherence in chronic conditions
- Effectively reduces joint stiffness, swelling, and tenderness in arthritic disorders
- Supports improved mobility and functional capacity in patients with degenerative joint diseases
- Offers a favorable benefit-risk profile when used as directed under medical supervision
- Helps reduce dependency on rescue analgesics by maintaining consistent therapeutic levels
Common use
Voveran SR is commonly prescribed for the management of chronic inflammatory and painful conditions. Its primary indications include osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also used off-label for acute gout flares, chronic low back pain, and postoperative pain management where sustained analgesia is required. The sustained-release formulation is particularly suited for patients requiring long-term anti-inflammatory and analgesic therapy, as it provides stable drug levels and reduces peak-trough fluctuations associated with immediate-release formulations.
Dosage and direction
The recommended dosage for adults is one 100 mg sustained-release tablet once daily, taken with food or milk to minimize gastrointestinal discomfort. Tablets should be swallowed whole and not crushed, chewed, or broken, as this alters the release kinetics. Dosage adjustment may be necessary in elderly patients or those with hepatic impairment, though generally should not exceed 100 mg daily. Treatment should be initiated at the lowest effective dose for the shortest duration consistent with treatment goals. For optimal absorption, administer at the same time each day.
Precautions
Use with caution in patients with a history of gastrointestinal ulceration or bleeding, cardiovascular disease, hypertension, renal impairment, or hepatic dysfunction. Periodic monitoring of renal function, liver enzymes, and hemoglobin is advised during long-term therapy. Patients should be advised to avoid alcohol and other NSAIDs concurrently due to increased risk of GI toxicity. Use during pregnancy, particularly in the third trimester, should be avoided due to potential risk of premature closure of the ductus arteriosus. Elderly patients are at increased risk of adverse reactions.
Contraindications
Voveran SR is contraindicated in patients with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation. It must not be used in patients with active peptic ulcer disease, history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Contraindications also include severe heart failure, recent coronary artery bypass graft (CABG) surgery, and severe renal or hepatic impairment. Should not be administered to patients in the third trimester of pregnancy.
Possible side effects
Common side effects include gastrointestinal disturbances such as dyspepsia, nausea, abdominal pain, and diarrhea. Others may include dizziness, headache, and peripheral edema. Serious adverse effects, though less common, include gastrointestinal bleeding or perforation, cardiovascular thrombotic events (e.g., myocardial infarction, stroke), hepatotoxicity, renal impairment, and severe skin reactions such as Stevens-Johnson syndrome. Patients should seek immediate medical attention for signs of bleeding, chest pain, shortness of breath, weakness on one side of the body, or slurred speech.
Drug interaction
Voveran SR may interact with anticoagulants (e.g., warfarin), antiplatelet agents, and selective serotonin reuptake inhibitors (SSRIs), increasing the risk of bleeding. Concurrent use with other NSAIDs or corticosteroids elevates gastrointestinal toxicity. It may reduce the effect of antihypertensive agents and diuretics. Caution is advised with cyclosporine, lithium, methotrexate, and digoxin due to potential increased plasma levels and toxicity. CYP2C9 inhibitors may increase diclofenac concentrations.
Missed dose
If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the usual dosing schedule. Do not double the dose to make up for a missed one. Maintaining consistent timing is important to ensure stable therapeutic levels, but occasional missed doses are unlikely to significantly impact long-term efficacy.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, and seizures. Hypertension, acute renal failure, and respiratory depression are possible in severe cases. There is no specific antidote; management is supportive and includes gastric lavage or activated charcoal if presented early. Hemodialysis is not effective due to high protein binding. Symptomatic treatment and monitoring of vital organs are essential.
Storage
Store at room temperature (15–30°C), in a dry place, protected from light and moisture. Keep in the original container with the lid tightly closed. Do not store in bathrooms or near sinks. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read here. The use of Voveran SR should be under appropriate medical supervision.
Reviews
Clinical studies and patient reports indicate that Voveran SR is effective in reducing pain and improving function in chronic inflammatory conditions. Many users report significant improvement in quality of life, with particular appreciation for the once-daily dosing. Some note gastrointestinal side effects as a drawback, though these are often manageable with concomitant gastroprotective agents. Overall, it is regarded as a reliable option for long-term NSAID therapy when monitored appropriately.