Xenical: Clinically Proven Weight Loss with Orlistat
Xenical
| Product dosage: 120mg | |||
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| Product dosage: 60mg | |||
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Synonyms | |||
Xenical (orlistat 120 mg) is a prescription-only lipase inhibitor indicated for obesity management in conjunction with a reduced-calorie diet. It functions by inhibiting the absorption of dietary fats in the gastrointestinal tract, leading to a caloric deficit. This medication is specifically designed for adults with a body mass index (BMI) of 30 kg/m² or greater, or 27 kg/m² or greater in the presence of other risk factors such as hypertension, diabetes, or dyslipidemia. Treatment should be initiated under medical supervision as part of a comprehensive weight management strategy.
Features
- Active ingredient: Orlistat 120 mg per capsule
- Mechanism: Reversible inhibitor of gastrointestinal lipases
- Administration: Oral capsule
- Packaging: Available in packs of 21, 42, or 84 capsules
- Prescription status: Rx-only medication
- Manufacturer: Originally developed by Roche, now available as generic orlistat
Benefits
- Promotes clinically significant weight loss when combined with a hypocaloric diet
- Reduces absorption of dietary fat by approximately 30%
- Improves obesity-related comorbidities including glycemic control in type 2 diabetes
- Lowers LDL cholesterol and total cholesterol levels
- Provides sustainable weight management support with long-term use
- Helps establish healthier eating patterns through behavioral feedback mechanism
Common use
Xenical is primarily prescribed for the management of obesity in adults. It is indicated for patients with an initial BMI ≥30 kg/m², or ≥27 kg/m² when other risk factors (such as hypertension, type 2 diabetes, or dyslipidemia) are present. The medication is used as an adjunct to a medically supervised reduced-calorie diet and should be incorporated into a comprehensive weight management program that includes nutritional education, increased physical activity, and behavioral modification. Treatment is typically recommended for patients who have not achieved adequate weight loss through diet and exercise alone.
Dosage and direction
The recommended dosage of Xenical is one 120 mg capsule taken three times daily with each main meal containing fat. The medication may be taken during the meal or up to one hour after eating. If a meal is missed or contains no fat, the dose of Xenical may be omitted. The capsules should be swallowed whole with water. Daily fat intake should be distributed evenly over three main meals. A multivitamin supplement containing fat-soluble vitamins (A, D, E, and K) should be taken once daily at least 2 hours before or after Xenical administration to prevent potential deficiency.
Precautions
Patients should be advised to follow a nutritionally balanced, reduced-calorie diet that derives approximately 30% of calories from fat. Higher fat intake may increase the likelihood of gastrointestinal adverse effects. Regular physical activity should be maintained throughout treatment. Hepatic function should be monitored periodically, as rare cases of severe liver injury have been reported. Patients should be counseled about the possibility of decreased cyclosporine absorption; concomitant use requires close monitoring of cyclosporine levels. Those with chronic malabsorption syndrome or cholestasis should use Xenical with caution. Pregnancy should be excluded before initiation and adequate contraception maintained during treatment.
Contraindications
Xenical is contraindicated in patients with chronic malabsorption syndrome, cholestasis, known hypersensitivity to orlistat or any component of the formulation, and during pregnancy and breastfeeding. It should not be used by patients with anorexia nervosa or bulimia nervosa. Concomitant use with cyclosporine is contraindicated unless specifically recommended by a healthcare provider with appropriate monitoring. The medication is not recommended for pediatric patients under 18 years of age.
Possible side effects
The most common adverse reactions are gastrointestinal in nature and result from the pharmacological mechanism of action. These include:
- Oily spotting (27%)
- Flatus with discharge (24%)
- Fecal urgency (22%)
- Fatty/oily stool (20%)
- Oily evacuation (12%)
- Increased defecation (11%)
- Fecal incontinence (8%)
These effects are generally mild to moderate, decrease with continued use, and are often associated with high-fat meals. Other reported side effects include abdominal pain/discomfort, nausea, infectious diarrhea, rectal pain/discomfort, tooth disorder, gingival disorder, headache, upper respiratory infection, and back pain. Rare cases of hypersensitivity reactions, including anaphylaxis, have been reported.
Drug interaction
Xenical may reduce the absorption of fat-soluble vitamins (A, D, E, K) and beta-carotene. Patients should take a multivitamin supplement containing these nutrients at least 2 hours before or after Xenical administration. The medication may decrease the absorption of amiodarone, cyclosporine, levothyroxine, antiepileptic drugs, and oral contraceptives. Patients taking these medications should be monitored closely and may require dosage adjustments. Concurrent administration with pravastatin may increase the lipid-lowering effects. Xenical does not affect the pharmacokinetics of alcohol, digoxin, phenytoin, oral contraceptives, nifedipine, or glyburide.
Missed dose
If a dose is missed, it should be skipped and the regular dosing schedule resumed with the next meal. Patients should not take a double dose to make up for a missed dose. The medication is only effective when taken with meals containing fat, so taking it without food provides no therapeutic benefit and may increase the risk of side effects without efficacy.
Overdose
There have been no reports of serious adverse events from Xenical overdose. Single doses of 800 mg and multiple doses up to 400 mg three times daily for 15 days have been studied without significant adverse effects. In cases of suspected overdose, medical attention should be sought. Treatment should be symptomatic and supportive. The likelihood of systemic effects is low due to minimal absorption of the drug.
Storage
Store Xenical capsules at room temperature between 15-30°C (59-86°F). Keep the container tightly closed and protect from moisture. Do not store in the bathroom or near sinks. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Properly discard any unused medication according to local regulations.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Xenical is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Individual results may vary. Patients should consult their healthcare provider for personalized medical advice, including assessment of potential risks and benefits based on their complete medical history. Never disregard professional medical advice or delay seeking treatment because of information contained in this document.
Reviews
Clinical studies demonstrate that Xenical, when combined with a reduced-calorie diet, produces significantly greater weight loss than placebo alone. In one-year trials, approximately 40% of patients achieved ≥5% weight loss, and 20% achieved ≥10% weight loss. Long-term studies over four years show maintained weight reduction and reduced incidence of type 2 diabetes in obese patients with normal glucose tolerance at baseline. Patient experiences vary, with many reporting successful weight management when adhering to dietary recommendations, while others discontinue due to gastrointestinal side effects. Healthcare providers generally consider Xenical an effective option for appropriate patients committed to comprehensive lifestyle modification.