

Lasix
Product dosage: 100mg | |||
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Lasix: Effective Diuretic for Rapid Fluid Reduction
Lasix (furosemide) is a potent loop diuretic widely prescribed for the management of edema associated with congestive heart failure, liver cirrhosis, and renal disease. It works by inhibiting sodium and chloride reabsorption in the ascending loop of Henle, leading to significant water excretion. This medication is valued in clinical practice for its rapid onset, predictable pharmacokinetics, and well-established safety profile when used under appropriate medical supervision.
Features
- Active ingredient: Furosemide 20 mg, 40 mg, or 80 mg tablets
- Mechanism: Loop diuretic inhibiting Na⁺-K⁺-2Cl⁻ cotransporter
- Onset of action: Oral administration—within 60 minutes; IV—within 5 minutes
- Duration: 6–8 hours (oral)
- Bioavailability: 60–70%
- Half-life: Approximately 2 hours (prolonged in renal impairment)
- Excretion: Primarily renal (unchanged drug and metabolites)
Benefits
- Rapid reduction of peripheral and pulmonary edema
- Decreased cardiac preload in acute heart failure exacerbations
- Effective management of hypertension, especially in volume-overloaded states
- Useful in hypercalcemia due to enhanced calcium excretion
- Adjunctive therapy in cerebral edema (with caution)
- Facilitates fluid balance in nephrotic syndrome and cirrhosis
Common use
Lasix is primarily indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disorders, including nephrotic syndrome. It is also used in the management of hypertension, either as monotherapy or in combination with other antihypertensive agents. Off-label uses include treatment of hypercalcemia and, in certain clinical scenarios, elevated intracranial pressure.
Dosage and direction
Dosage must be individualized based on patient response, renal function, and clinical condition. For edema in adults: initial dose is 20–80 mg orally once or twice daily; may be increased by 20–40 mg every 6–8 hours until desired diuresis is achieved. Maintenance doses typically range from 20 mg to 600 mg daily, though most patients are maintained on 40–120 mg daily. For hypertension:起始剂量为40 mg口服,每日两次,根据血压反应调整。 IV administration is reserved for urgent situations (e.g., acute pulmonary edema) at 20–40 mg, repeated or increased as needed. Administer in the morning to avoid nocturia.
Precautions
Monitor serum electrolytes (especially potassium, sodium, and magnesium), renal function, and volume status regularly. Use with caution in patients with sulfonamide allergy (cross-sensitivity possible), hepatic impairment, or gout. May cause ototoxicity, particularly with rapid IV administration, high doses, or concomitant use of other ototoxic drugs. Avoid in hypovolemic or hypotensive patients. Elderly patients are more susceptible to dehydration and electrolyte disturbances.
Contraindications
Anuria; hypersensitivity to furosemide or sulfonamide-derived drugs; hepatic coma or severe electrolyte depletion; patients in whom diuresis is undesirable (e.g., in toxicant-induced pulmonary edema without fluid overload).
Possible side effect
Common: dehydration, hypokalemia, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hyperuricemia, dizziness, headache.
Less common: ototoxicity (tinnitus, hearing loss), orthostatic hypotension, pancreatitis, photosensitivity, blood dyscrasias (e.g., thrombocytopenia), rash.
Rare: interstitial nephritis, exacerbation of systemic lupus erythematosus, Stevens-Johnson syndrome.
Drug interaction
- Enhanced hypotensive effect with other antihypertensives
- Increased risk of ototoxicity with aminoglycosides, cisplatin
- Reduced diuretic effect with NSAIDs, probenecid
- Hypokalemia potentiated by corticosteroids, amphotericin B, stimulant laxatives
- Lithium toxicity possible due to reduced renal clearance
- Digoxin toxicity risk increased with hypokalemia
- Synergistic nephrotoxicity with cephalosporins or vancomycin
Missed dose
If a dose is missed, take it as soon as remembered unless it is near the time for the next dose. Do not double the dose. For once-daily regimens, if missed entirely, resume the next day at the usual time.
Overdose
Symptoms include profound water and electrolyte depletion (manifested as weakness, dizziness, confusion, arrhythmias), dehydration, and circulatory collapse. Treatment is supportive: discontinue Lasix, replace fluid and electrolytes intravenously, and monitor cardiac and renal function. Hemodialysis does not significantly remove furosemide.
Storage
Store at room temperature (15–30°C) in a tightly closed container, protected from light and moisture. Keep out of reach of children. Do not use after expiration date.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Lasix is a prescription medication and should be used only under the supervision of a qualified healthcare provider. Dosage, indications, and monitoring must be individualized based on clinical evaluation. Always consult with a physician for diagnosis and treatment recommendations.
Reviews
(Compiled from clinical studies and therapeutic guidelines)
Lasix remains a cornerstone in diuretic therapy due to its efficacy, rapid action, and extensive clinical experience. In heart failure management, it significantly improves symptoms of fluid overload and reduces hospitalizations. Critics note the need for careful electrolyte monitoring and the risk of over-diuresis. Overall, it is considered a first-line agent in indicated conditions when used appropriately.